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> Tetrapeptide-4 [960608-16-6]

Tetrapeptide-4 [960608-16-6]

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Référence HY-P5237-5mg

Conditionnement : 5mg

Marque : MedChemExpress


Description

Tetrapeptide-4 is a synthetic tetrapeptide. Tetrapeptide-4 upregulates hyaluronic acid synthetase, and collagen production in human dermal fibroblasts. Tetrapeptide-4 reduces skin aging, improves skin firmness, elasticity, and appearance, and benefits hair[1].

IC50 & Target[1]

Collagen I

 

Collagen II

 

In Vitro

Tetrapeptide-4 (compound GEPG) (1 μg/mL; 24 h) upregulates FN1, HAS1, COL1A1, and COL1A2 mRNA expression in human dermal fibroblasts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrapeptide-4 Related Antibodies

Real Time qPCR[1]

Cell Line: human dermal fibroblasts (HDFs) derived from neonatal foreskin
Concentration: 1 μg/mL
Incubation Time: 24 h
Result: Increased fibronectin 1 (FN1) mRNA expression to a normalized level of 17 relative to control.
Increased hyaluronic acid synthetase 1 (HAS1) mRNA expression.
Increased collagen I alpha-1 chain (COL1A1) mRNA expression.
Increased collagen I alpha-2 chain (COL1A2) mRNA expression.
Masse moléculaire

358.35

Formule

C14H22N4O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Glu-Pro-Gly
Sequence Shortening

GEPG
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

DMSO : 33.33 mg/mL (93.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7906 mL 13.9528 mL 27.9057 mL
5 mM 0.5581 mL 2.7906 mL 5.5811 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références