Clinisciences > TNFSF10 Antibody - HRP Conjugated
TNFSF10 Antibody - HRP Conjugated
Référence OACA01460
Conditionnement : 100ug
Marque : Aviva Systems Biology
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TNFSF10 Antibody - HRP Conjugated (OACA01460)
| Datasheets/Manuals | Printable datasheet for TNFSF10 Antibody - HRP Conjugated (OACA01460) (OACA01460) |
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| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | HRP |
| Application | ELISA |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Tumor necrosis factor ligand superfamily member 10 protein (39-281AA) |
| Purification | Protein G Purified |
| Purity | Caprylic Acid Ammonium Sulfate Precipitation purified |
| Storage Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Reference | [1] Identification and characterization of a new member of the TNF family that induces apoptosis.'Wiley S.R., Schooley K., Smolak P.J., Din W.S., Huang C.-P., Nicholl J.K., Sutherland G.R., Davis-Smith T., Rauch C., Smith C.A., Goodwin R.G.Immunity 3:673-682(1995) [PubMed: 8777713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] [2] Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.'Pitti R.M., Marsters S.A., Ruppert S., Donahue C.J., Moore A., Ashkenazi A.J. Biol. Chem. 271:12687-12690(1996) [PubMed: 8663110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] Tissue: Placenta. |
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| Gene Symbol | TNFSF10 |
| Gene Full Name | TNF superfamily member 10 |
| Alias Symbols | Apo-2 ligand;Apo-2L;APO2L;CD253;chemokine tumor necrosis factor ligand superfamily member 10;TL2;TNF-related apoptosis inducing ligand TRAIL;TNF-related apoptosis-inducing ligand;TNLG6A;TRAIL;tumor necrosis factor (ligand) family, member 10;tumor necrosis factor (ligand) superfamily, member 10;tumor necrosis factor apoptosis-inducing ligand splice variant delta;tumor necrosis factor ligand 6A;tumor necrosis factor ligand superfamily member 10;tumor necrosis factor superfamily member 10. |
| NCBI Gene Id | 8743 |
| Protein Name | Tumor necrosis factor ligand superfamily member 10 |
| Description of Target | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
| Uniprot ID | P50591 |
Protein interactions
| Name | # of Products | |||||
|---|---|---|---|---|---|---|
| ACP5 | 32 | |||||
| CREBBP | 802 | |||||
| HDAC1 | 928 | |||||
| HDAC2 | 549 | |||||
| HDAC3 | 422 | |||||
| HDAC4 | 233 | |||||
| HDAC5 | 906 | |||||
| HIST3H3 | 224 | IER3 | 15 | |||
| RBM48 | 100 | |||||
| SP1 | 551 | |||||
| SP3 | 46 | |||||
| TNFRSF10A | 62 | 40 | 41 | 40 | 55 | 49 |
Biological pathways
| Name | # of Products |
|---|---|
| Activation of cysteine-type endopeptidase activity involved in apoptotic process | 193 |
| Activation of pro-apoptotic gene products | 157 |
| Cell-cell signaling | 763 |
| Immune response | 1416 |
| Induction of apoptosis by extracellular signals | 243 |
| Positive regulation of I-kappaB kinase/NF-kappaB cascade | 414 |
| Signal transduction | 939 |
Biological process
| Name | # of Products |
|---|---|
| Activation of cysteine-type endopeptidase activity involved in apoptotic process | 100 |
| Activation of pro-apoptotic gene products | 31 |
| Apoptotic process | 586 |
| Cell-cell signaling | 235 |
| Immune response | 404 |
| Induction of apoptosis | 226 |
| Induction of apoptosis by extracellular signals | 104 |
| Positive regulation of extrinsic apoptotic signaling pathway | 14 |
| Positive regulation of I-kappaB kinase/NF-kappaB cascade | 160 |
| Signal transduction | 1058 |
Cellular components
| Name | # of Products |
|---|---|
| Extracellular region | 1573 |
| Extracellular space | 884 |
| Integral to plasma membrane | 817 |
| Membrane | 2769 |
| Soluble fraction | 338 |
Protein function
| Name | # of Products |
|---|---|
| Cytokine activity | 1104 |
| Metal ion binding | 5514 |
| Protein binding | 12191 |
| Receptor binding | 932 |
| Tumor necrosis factor receptor binding | 237 |
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