Rat Anti-Mouse CD102-AF488
Référence 1925-30
Conditionnement : 0.1mg
Marque : Southern Biotech
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| Clone | 3C4 |
|---|---|
| Isotype | Rat (Lewis) IgG2aκ |
| Isotype Control | Rat IgG2a-AF488 (KLH/G2a-1-1) |
| Specificity | Mouse CD102 |
| Alternative Names | ICAM-2, intercellular adhesion molecule-2 |
| Description | The 3C4 monoclonal antibody reacts with the cell surface glycoprotein mouse CD102 (ICAM-2), a ligand for the leucocyte integrin CD11a/CD18 (LFA-1). CD102 is constitutively expressed on T cells, B cells, and at high levels on vascular endothelial cells. It is also expressed on a variety of leukocyte cell lines. The 3C4 antibody blocks the interaction between ICAM-2 and LFA-1. |
| Immunogen | COS cells transfected with mouse ICAM-2 cDNA and BW5147 AKR/J mouse thymoma cell line |
| Conjugate | AF488 (Alexa Fluor® 488) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 0.2 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light |
| Trademark Information | Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
| Applications | Flow Cytometry – Quality tested 1,5 Immunohistochemistry-Frozen Sections – Reported in literature 2,3 Immunocytochemistry – Reported in literature 4,5 Immunoprecipitation – Reported in literature 1 Blocking – Reported in literature 1 |
| RRID Number | AB_2795546 |
| Gene ID | 15896 (Mouse) |
| Gene ID Symbol | Icam2 (Mouse) |
| Gene ID Aliases | CD102; Icam-2; Ly-60 |
| UniProt ID | P35330 (Mouse) |
| UniProt Name | ICAM2_MOUSE (Mouse) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 1. Xu H, Bickford JK, Luther E, Carpenito C, Takei F, Springer TA. Characterization of murine intercellular adhesion molecule-2. J Immunol. 1996;156:4909-14. (Immunogen, FC, IP, Block)
- 2. Cao G, Savani RC, Fehrenbach M, Lyons C, Zhang L, Coukos G, et al. Involvement of endothelial CD44 during in vivo angiogenesis. Am J Pathol. 2006;169:325-36. (IHC-FS)
- 3. Cao G, Fehrenbach ML, Williams JT, Finklestein JM, Zhu J, DeLisser HM. Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice. Am J Pathol. 2009;175:903-15. (IHC-FS)
- 4. Shin J, Lee JC, Baek K. A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. Cancer Lett. 2014;342:70-81. (ICC)
- 5. Fehrenbach ML, Cao G, Williams JT, Finklestein JM, DeLisser HM. Isolation of murine lung endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2009;296:L1096-1103. (ICC, FC)