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(-)-borneol [464-45-9]

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Référence NB-64-25116-100mg

Conditionnement : 100mg

Marque : Neo Biotech

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(-)-borneol (Synonyms: L-Borneol)

Catalog No. T3741 Copy Product Info

Purity: 99.02%

(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.

(-)-borneol

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Synonyms L-Borneol

(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.

Cas No. 464-45-9

Batch Information

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Purity:99.02%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

(-)-borneol AI Summary

(-)-borneol exhibits a binding affinity against human UDP Glucuronosyltransferase 1A4 (UGT1A4), with a Km value of 1100000.0 nM, and shows varying bioactivities across different human recombinant UGT isoforms. It demonstrates low or no activity in UGT1A1, UGT2B15, and UGT2B7H, while displaying moderate to high activity in UGT2A1, UGT2B7Y, and UGT1A4. The compound also exhibits antifungal activity against Colletotrichum acutatum, Colletotrichum gloeosporioides, and Colletotrichum fragariae, as observed in direct bioautography assays using 4 uL in 2 mM acetone, with complete growth inhibition. Furthermore, (-)-borneol displays cytotoxicity against HEK293 cells with a CC50 greater than 3000000.0 nM and inhibits Marburg virus envelope glycoprotein-mediated cell entry with an IC50 of 203000.0 nM. However, it shows weaker inhibition of Vesicular stomatitis Indiana virus envelope glycoprotein G-mediated cell entry with an IC50 greater than 650000.0 nM, yielding a selectivity index greater than 14.0 for Marburg virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
Targets&IC50	GABA:237 μM(EC50)
Synonyms	L-Borneol

Chemical Properties

Molecular Weight	154.25
Formula	C₁₀H₁₈O
Cas No.	464-45-9
Smiles	C[C@]12C(C)(C)[C@](C[C@H]1O)(CC2)13
Relative Density.	0.992g/cm3

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform: Soluble

DMSO: 250 mg/mL (1620.75 mM), Sonication is recommended.

Ethanol: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4830 mL	32.4149 mL	64.8298 mL	324.1491 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL	64.8298 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
20 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	6.4830 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.