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> α-Humulene [6753-98-6]

α-Humulene [6753-98-6]

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Référence orb1297468-1ml

Conditionnement : 1mlx10mM(inDMSO)

Marque : Biorbyt


α-Humulene

SKU: orb1297468

Description

α-Humulene, a sesquiterpene isolated from Salvia officinalis essential oil, exhibits antitumor and anti-inflammatory properties. Its mechanisms involve suppressing tumor cell proliferation and modulating inflammatory pathways by inhibiting TNF-α production and downregulating COX-2 and iNOS expression, as demonstrated in various in vitro and in vivo research models.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Images & Validation

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α-Humulene

Key Properties

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CAS Number6753-98-6
MW204.35
Purity99.70% (May vary between batches)
FormulaC15H24
SMILESCC1(C)/C=C\C/C(C)=C\CC/C(C)=C\C1
TargetCOX,TNF,NOS,NO Synthase
SolubilityEthanol:Soluble;10% DMSO+90% Corn Oil:2.5 mg/mL (12.23 mM);DMSO:50 mg/mL (244.68 mM);Ether:Soluble

Bioactivity

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In Vitro
S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography; the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS). The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) values of 90.5 and 145.8 mu g/ml.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Cyclooxygenase, COX, a-Humulene, alpha-Humulene, Alpha-caryophyllene, a-caryophyllene, Humulene, iNOS, Inhibitor, NO Synthase, Nitric oxide synthases, inhibit, NOS, TNF-α, α-Caryophyllene, α-caryophyllene, α Humulene, αHumulene, α-Humulene
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  • β-Caryophyllene

    β-Caryophyllene [orb1221705]

    >98% (HPLC)

    87-44-5

    204.35

    C15H24

    500 mg, 1 g
  • α-Humulene

    α-Humulene [orb1940118]

    >98% (HPLC)

    6753-98-6

    204.357

    C15H24

    1 g, 200 mg, 500 mg, 100 mg

Compound Identifiers

PubChem CID
5281520 ↗

Key Properties

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