Albendazole [54965-21-8]
Référence T1152-50mg
Conditionnement : 50mg
Marque : TargetMol
Albendazole
(Synonyms: SKF-62979) Copy Product Info
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
Cas No. 54965-21-8
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.76%
Appearance:Solid
Color:White
COA LCMS HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations. |
| In vitro | In sheep lambs administered Albendazole intravenously, the drug and its active metabolite, albendazole sulfoxide, are recovered in tapeworms. In rats, Albendazole significantly increases hepatic activity: it induces a 65-fold increase in CYP1A1-related ethoxyresorufin O-deethylase (EROD) activity, a 6-fold increase in CYP1A2-related methoxyresorufin O-demethylase activity, a 4-fold increase in CYP2B1-related pentoxyresorufin O-dealkylase activity, a 14-fold increase in CYP2B2-related benzyloxyresorufin O-dealkylase activity, and also leads to a partial reduction in CYP2E1-related p-nitrophenol hydroxylase activity. Albendazole is metabolized by liver and lung microsomes in sheep and cattle as well as bovine intestinal microsomes into its pharmacologically active sulfoxide metabolite. |
| In vivo | Albendazole and its sulfoxide metabolites induce the accumulation of cells in the mitotic phase. |
| Synonyms | SKF-62979 |
| Molecular Weight | 265.33 |
| Formula | C12H15N3O2S |
| Cas No. | 54965-21-8 |
| Smiles | N(C(OC)=O)C=1NC=2C(N1)=CC(SCCC)=CC2 |
| Relative Density. | 1.2561 g/cm3 (Estimated) |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (94.22 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Saline: < 2.5 mg/mL (9.42 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.42 mM), Suspension. 10% DMSO+90% Corn Oil: 1 mg/mL (3.77 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||