Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-Recommended for use at 0.1-1µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ADAM17
Gene ID:	6868
Uniprot ID:	ADA17_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_003174.3
Specificity:	This antibody is expected to recognise isoform 1 (represented by NP_003174.3) and not isoform 2 (represented by NP_068604).
Immunogen Sequence:	LQRQNRVDSKETEC

Post Translational Modifications	The precursor is cleaved by a furin endopeptidase. Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at Thr-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells.
Protein Name	Disintegrin And Metalloproteinase Domain-Containing Protein 17 Adam 17 Snake Venom-Like Protease Tnf-Alpha Convertase Tnf-Alpha-Converting Enzyme Cd Antigen Cd156b
Database Links	Reactome: R-HSA-1251985 Reactome: R-HSA-1442490 Reactome: R-HSA-177929 Reactome: R-HSA-193692 Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2660826 Reactome: R-HSA-2691232 Reactome: R-HSA-2894862 Reactome: R-HSA-5362798 Reactome: R-HSA-75893 Reactome: R-HSA-9662834 Reactome: R-HSA-982772
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 17 antibody Anti-Adam 17 antibody Anti-Snake Venom-Like Protease antibody Anti-Tnf-Alpha Convertase antibody Anti-Tnf-Alpha-Converting Enzyme antibody Anti-Cd Antigen Cd156b antibody Anti-ADAM17 antibody Anti-CSVP antibody Anti-TACE antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance