General Information
| Short Description | Rabbit polyclonal EOMES (463-686) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID | |
| Immunogen Region | 463-686 |
| Immunogen Sequence | QIVPGGRYGVQSFFPEPFVN TLPQARYYNGERTVPQTNGL LSPQQSEEVANPPQRWLVTP VQQPGTNKLDISSYESEYTS STLLPYGIKSLPLQTSHALG YYPDPTFPAMAGWGGRGSYQ RKMAAGLPWTSRTSPTVFSE DQLSKEKVKEEIGSSWIETP PSIKSLDSNDSGVYTSACKR RRLSPSNSSNENSPSIKCED INAEEYSKDTSKGMGGYYAF YTTP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 463-686 of human EOMES (NP_005433.2). |
Additional Info
| Tissue Specificity | Expressed in CD8+ T-cells. |
| Function | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Required for differentiation and migration of unipolar dendritic brush cells. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. |
| Protein Name | Eomesodermin HomologT-Box Brain Protein 2T-Brain-2Tbr-2 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Eomesodermin Homolog antibodyAnti-T-Box Brain Protein 2 antibodyAnti-T-Brain-2 antibodyAnti-Tbr-2 antibodyAnti-EOMES antibodyAnti-TBR2 antibody |
Information sourced from Uniprot.org