ATP-sensitive inward rectifier potassium channel 12or Kir2.2 is encoded by the gene KCNJ12. Kir2.2 is a member of the inward rectifier potassium ion channel family and plays a role controlling the resting membrane potential in muscle cells and neurons. Kir2.2 is an integral membrane protein that is expressed in heart, brain and in aortic endothelial cells. In brain, Kir2.2 is expressed throughout the forebrain and cerebellum. Diseases associated with KCNJ12 include Smith-Magenis Syndrome and Leber Congenital Amaurosis 16.
Purified by Protein A chromatography
Lot dependent: provided at 0.3-0.5 mg/mL
Monoclonal
N124B/38
IgG1
ICC
Mouse
Kcnj12 Irk2
48 kDa
Synthetic peptide amino acids 390-410 (cytoplasmic C-terminus) of rat Kir2.2 (accession number P52188)
Rat
Mouse, Rat
AB_2939752
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL490 Ex: 491 nm, Em: 515 nm
No cross-reactivity against Kir2.1 or Kir2.3
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
