Anti-NCAPD2 antibody

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NCAPD2
Gene ID:	9918
Uniprot ID:	CND1_HUMAN
Immunogen Region:	1250-1350
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1250-1350 of human NCAPD2 (NP_055680.3).
Immunogen Sequence:	FGDKLSDESIFSAFLSVVGK LRRGAKPEGKAIIDEFEQKL RACHTRGLDGIKELEIGQAG SQRAPSAKKPSTGSRYQPLA STASDNDFVTPEPRRTTRRH P

Post Translational Modifications	Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation.
Function	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
Protein Name	Condensin Complex Subunit 1 Chromosome Condensation-Related Smc-Associated Protein 1 Chromosome-Associated Protein D2 Hcap-D2 Non-Smc Condensin I Complex Subunit D2 Xcap-D2 Homolog
Database Links	Reactome: R-HSA-2514853
Cellular Localisation	Nucleus Cytoplasm Chromosome In Interphase Cells The Majority Of The Condensin Complex Is Found In The Cytoplasm While A Minority Of The Complex Is Associated With Chromatin A Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase Cells During Mitosis Most Of The Condensin Complex Is Associated With The Chromatin At The Onset Of Prophase The Regulatory Subunits Of The Complex Are Phosphorylated By Cdk1 Leading To Condensin's Association With Chromosome Arms And To Chromosome Condensation Dissociation From Chromosomes Is Observed In Late Telophase
Alternative Antibody Names	Anti-Condensin Complex Subunit 1 antibody Anti-Chromosome Condensation-Related Smc-Associated Protein 1 antibody Anti-Chromosome-Associated Protein D2 antibody Anti-Hcap-D2 antibody Anti-Non-Smc Condensin I Complex Subunit D2 antibody Anti-Xcap-D2 Homolog antibody Anti-NCAPD2 antibody Anti-CAPD2 antibody Anti-CNAP1 antibody Anti-KIAA0159 antibody

Information sourced from Uniprot.org

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