General Info
Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-PON1 (50-150) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Monoclonal |
Clone ID: | S0MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | PON1 |
Gene ID: | 5444 |
Uniprot ID: | PON1_HUMAN |
Immunogen Region: | 50-150 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PON1 (P27169). |
Immunogen Sequence: | TGSEDLEILPNGLAFISSGL KYPGIKSFNPNSPGKILLMD LNEEDPTVLELGITGSKFDV SSFNPHGISTFTDEDNAMYL LVVNHPDAKSTVELFKFQEE E |
Description
Tissue Specificity | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. |
Post Translational Modifications | Glycosylated. The signal sequence is not cleaved. Present in two forms, form B contains a disulfide bond, form A does not. |
Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
Protein Name | Serum Paraoxonase/Arylesterase 1Pon 1 Aromatic Esterase 1A-Esterase 1K-45Serum Aryldialkylphosphatase 1 |
Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-9754706 |
Cellular Localisation | SecretedExtracellular Space |
Alternative Antibody Names | Anti-Serum Paraoxonase/Arylesterase 1 antibodyAnti-Pon 1 antibodyAnti-Aromatic Esterase 1 antibodyAnti-A-Esterase 1 antibodyAnti-K-45 antibodyAnti-Serum Aryldialkylphosphatase 1 antibodyAnti-PON1 antibodyAnti-PON antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance