Clonality:	Monoclonal
Conjugation:	Unconjugated
Formulation:	Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol.
Purification:	Affinity purification
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-1:2000 IF 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PPARG
Gene ID:	5468
Uniprot ID:	PPARG_HUMAN
Immunogen Region:	C-Term
Specificity:	PPAR-Gamma Monoclonal Antibody detects endogenous levels of PPAR-Gamma protein.
Immunogen:	Purified recombinant human PPAR-Gamma (C-terminus) protein fragments expressed in E.coli.

Post Translational Modifications	O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes. Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity. Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO9.leading to proteasomal degradation.
Function	Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels. (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.
Protein Name	Peroxisome Proliferator-Activated Receptor Gamma Ppar-Gamma Nuclear Receptor Subfamily 1 Group C Member 3
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-381340 Reactome: R-HSA-383280 Reactome: R-HSA-4090294 Reactome: R-HSA-8943724 Reactome: R-HSA-9022707
Cellular Localisation	Nucleus Cytoplasm Redistributed From The Nucleus To The Cytosol Through A Map2k1/Mek1-Dependent Manner Noct Enhances Its Nuclear Translocation
Alternative Antibody Names	Anti-Peroxisome Proliferator-Activated Receptor Gamma antibody Anti-Ppar-Gamma antibody Anti-Nuclear Receptor Subfamily 1 Group C Member 3 antibody Anti-PPARG antibody Anti-NR1C3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance