General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-SIPA1L1 (1480-1700) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | SIPA1L1 |
| Gene ID: | 26037 |
| Uniprot ID: | SI1L1_HUMAN |
| Immunogen Region: | 1480-1700 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1480-1700 of human SIPA1L1 (NP_056371.1). |
| Immunogen Sequence: | TSKYLIGWKKPEGTINSVGF MDTRKRHQSDGNEIAHTRLR ASTRDLRASPKPTSKSTIEE DLKKLIDLESPTPESQKSFK FHALSSPQSPFPSTPTSRRA LHRTLSDESIYNSQREHFFT SRASLLDQALPNDVLFSSTY PSLPKSLPLRRPSYTLGMKS LHGEFSASDSSLTDIQETRR QPMPDPGLMPLPDTAADLDW SNLVDAAKAYEVQRASFFAA S |
Description
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2. Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome. |
| Function | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis. |
| Protein Name | Signal-Induced Proliferation-Associated 1-Like Protein 1Sipa1-Like Protein 1High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1E6-Targeted Protein 1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmCytoskeletonPostsynaptic DensitySynapseSynaptosomeAssociated With The Actin CytoskeletonDetected At Synapses And Dendritic Spines Of Cultured Hippocampal Neurons |
| Alternative Antibody Names | Anti-Signal-Induced Proliferation-Associated 1-Like Protein 1 antibodyAnti-Sipa1-Like Protein 1 antibodyAnti-High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1 antibodyAnti-E6-Targeted Protein 1 antibodyAnti-SIPA1L1 antibodyAnti-E6TP1 antibodyAnti-KIAA0440 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance