General Info
| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-SLC7A10 (450-500) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.50-0.75 µg/µl |
| Dilution Range: | WB: 1:500-1:1, 000DB: 1:4, 000ELISA: 1:4, 000IP: 1:200IHC: 1:50ICC: 1:50IF: 1:50CFM: 1:50 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | SLC7A10 |
| Gene ID: | 56301 |
| Uniprot ID: | AAA1_HUMAN |
| Immunogen Region: | 450-500 |
| Immunogen: | Synthetic peptide taken within amino acid region 450-500 on rat Asc-type amino acid transporter 1 protein. |
Description
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. |
| Function | Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons. At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment. |
| Protein Name | Asc-Type Amino Acid Transporter 1Asc-1Solute Carrier Family 7 Member 10 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinColocalizes With Olig2 In Astrocytic ProcessesLocalizes To The Plasma Membrane In Mature Adipocytes And To Intracellular Structures In Preadipocytes |
| Alternative Antibody Names | Anti-Asc-Type Amino Acid Transporter 1 antibodyAnti-Asc-1 antibodyAnti-Solute Carrier Family 7 Member 10 antibodyAnti-SLC7A10 antibodyAnti-ASC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance