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> Anti-TGF beta 1 Antibody (9U614)

Anti-TGF beta 1 Antibody (9U614)

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Référence NB-64-114398-200uL

Conditionnement : 200uL

Marque : Neo Biotech


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Anti-TGF beta 1 Antibody (9U614)

(Synonyms: transforming growth factor, β1, transforming growth factor, beta 1, TGF β1) Copy Product Info

Synonyms: transforming growth factor, β1, transforming growth factor, beta 1, TGF β1

Catalog No. TMAB-01826 Copy Product Info
Anti-TGF beta 1 Antibody (9U614) is a Mouse antibody targeting TGF beta 1. Anti-TGF beta 1 Antibody (9U614) can be used in IF,IHC-Fr,IHC-P.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-TGF beta 1 Antibody (9U614) is a Mouse antibody targeting TGF beta 1. Anti-TGF beta 1 Antibody (9U614) can be used in IF,IHC-Fr,IHC-P.
Synonymstransforming growth factor, β1, transforming growth factor, beta 1, TGF β1
Ig Type
IgG1
Clone
9U614
Reactivity
Rat,Mouse (predicted:Human)
Verified Activity
1. Paraformaldehyde-fixed, paraffin embedded (rat spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (TGF beta 1) Monoclonal Antibody, Unconjugated (TMAB-01826) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Mouse) instructionsand DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded (mouse spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (TGF beta 1) Monoclonal Antibody, Unconjugated (TMAB-01826) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Mouse) instructionsand DAB staining.
Anti-TGF beta 1 Antibody (9U614),Anti-TGF beta 1 Antibody (9U614)
Application
IF
IHC-Fr
IHC-P
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationSecreted, extracellular space, extracellular matrix.
Tissue SpecificityHighly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThis gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human TGF beta 1
Antigen Species
Human
Gene Name
TGFB1
Gene ID
7040
Protein Name
Transforming growth factor beta-1 proprotein
Uniprot ID
P01137
Biology Area
Response to hypoxia,TGF,Angiogenic growth factors,TGF,Co-factors,Hypoxia,tgf beta 1,TGF,Secreted
Function
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
Chemical Properties
Molecular WeightTheoretical: 12.8/44 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Keywords

transforming growth factor, β 1transforming growth factor, b 1
Related Tags: Anti-TGF beta 1 Antibody (9U614) chemical structure | Anti-TGF beta 1 Antibody (9U614) molecular weight