General Info
Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-TWEAKR/Fn14/CD266 (50-129) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Monoclonal |
Clone ID: | S7MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | TNFRSF12A |
Gene ID: | 51330 |
Uniprot ID: | TNR12_HUMAN |
Immunogen Region: | 50-129 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-129 of human TWEAKR/Fn14/CD266 (Q9NP84). |
Immunogen Sequence: | MDCASCRARPHSDFCLGCAA APPAPFRLLWPILGGALSLT FVLGLLSGFLVWRRCRRREK FTTPIEETGGEGCPAVALIQ |
Description
Tissue Specificity | Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. |
Function | Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. |
Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 12aFibroblast Growth Factor-Inducible Immediate-Early Response Protein 14Fgf-Inducible 14Tweak-ReceptorTweakrCd Antigen Cd266 |
Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 12a antibodyAnti-Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 antibodyAnti-Fgf-Inducible 14 antibodyAnti-Tweak-Receptor antibodyAnti-Tweakr antibodyAnti-Cd Antigen Cd266 antibodyAnti-TNFRSF12A antibodyAnti-FN14 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance