Atelocollagen Sponge, MIGHTY
KKN-CSM-25 / KKN-CSM-50
Brand: AteloCell®
Type 1 Atelocollagen sponge with heightened resistance to compressive loading.
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Product Information
A "physically strong" collagen sponge (96-well plate size) derived from bovine dermal type I collagen that shows resistance to compressive loading. Culturing with dynamic stimulus (such as pressure) can mimic in-vivo-like cell response as shown in some arthritic cell culture models.
Applications
- Cell culture under dynamic stimuli
- 3D cell culture
- Carrier for cell transplant
Features
- Retains structural rigidity during repeated compression loading of 10-20 kPa
- Sized for 96 well plates
Data
"Mechanical stimulus culture assay using MIGHTY." (K. Shimomura, K. Nakata et al. Osaka University, Faculty of Medicine)
Forty kPa of repeated compressive load for 1 hour induced the expression of PEG2, IL6 and IL8, which are correlated to arthritis, after three days cultivation on MIGHTY.
Dexamethasone (Dex), anti-inflammatory agent, reduced the expression of PEG2, IL6 and IL8 in a concentration-dependent manner. These results indicate MIGHTY can be used for in vitro arthritis models.
KOKEN company name and logo and AteloCell brand are the property of KOKEN Corp. Ltd., Japan.