CD45 / LCA Rat Monoclonal Antibody [Clone ID: I3/2.3]

CAT#: AM08044AC7-N

CD45 / LCA rat monoclonal antibody, clone I3/2.3, APC-Cy7


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Specifications

Product Data
Clone Name I3/2.3
Applications IHC
Recommended Dilution Flow Cytometry: < / = 0.2 µg/10e6 cells. (Ref.4,5)
Reactivities Mouse
Host Rat
Isotype IgG2b
Clonality Monoclonal
Specificity This antibody recognizes a framework epitope present on all CD45 isoforms. (Ref.3-6)
Formulation PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent.
Label: APC-Cy7
State: Liquid purified Ig fraction.
Label: Allophycocyanin-Cyanine 7
Concentration lot specific
Conjugation APC-Cy7
Storage Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name protein tyrosine phosphatase, receptor type, C
Background CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 while those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Synonyms PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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