DTNB [69-78-3]
Référence NB-64-06458-1g
Conditionnement : 1g
Marque : Neo Biotech
DTNB (Synonyms: Ellman's Reagent)
Catalog No. T15177 Copy Product Info
Purity: 99.51%
DTNB (Ellman's Reagent) is used to quantify thiol groups in a sample and measure low-molecular-mass thiols, such as glutathione, in pure solutions and biological samples [such as blood].
DTNB
Copy Product InfoSynonyms Ellman's Reagent
DTNB (Ellman's Reagent) is used to quantify thiol groups in a sample and measure low-molecular-mass thiols, such as glutathione, in pure solutions and biological samples [such as blood].
Cas No. 69-78-3
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Purity:99.51%
Appearance:Solid
Color:White to Yellow
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Product Introduction
DTNB-64-06458-1g Summary
DTNB-64-06458-1g the binding of wild type HIV YU2 gp120 to CD4 with an IC50 value of 3580.0 nM. It also targets human thymidylate kinase, showing an IC50 value of 1530.0 nM in the presence of dTMP substrate using fluorescence analysis after 30 minutes. Additionally, DTNB-64-06458-1g inhibitory activity against various exonuclease enzymes, such as Escherichia coli K-12 RNase T exonuclease, Caenorhabditis elegans CRN-4 exonuclease, and Lassa virus NP exonuclease domain, with inhibitory concentrations of 0.1 mM for the first two enzymes and 1.0 mM for the latter. Moreover, the compound displays substrate activity with recombinant Haemophilus influenzae Chloramphenicol nitroreductase expressed in Escherichia coli, with an activity rate of 3.5% measured under specified conditions. This multifaceted profile suggests potential use as a broad-spectrum inhibitor of enzyme activities..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DTNB (Ellman's Reagent) is used to quantify thiol groups in a sample and measure low-molecular-mass thiols, such as glutathione, in pure solutions and biological samples [such as blood]. |
| Synonyms | Ellman's Reagent |
| Molecular Weight | 396.35 |
| Formula | C14H8N2O8S2 |
| Cas No. | 69-78-3 |
| Smiles | C(O)(=O)C1=C(N(=O)=O)C=CC(SSC2=CC(C(O)=O)=C(N(=O)=O)C=C2)=C1 |
| Relative Density. | 1.67 g/cm3 |
| Storage | ||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 247.5 mg/mL (624.45 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.31 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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