Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Ercalcitriol [60133-18-8]

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Référence NB-64-69266-1mg

Conditionnement : 1mg

Marque : Neo Biotech

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Ercalcitriol (Synonyms: 1α,25-Dihydroxy Vitamin D2)

Catalog No. TQ0216 Copy Product Info

Purity: 99.02%

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2 that strengthens immunity by regulating cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells, combating pathogenic infections.

Ercalcitriol

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Synonyms 1α,25-Dihydroxy Vitamin D2

Cas No. 60133-18-8

Batch Information

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Purity:99.02%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2 that strengthens immunity by regulating cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells, combating pathogenic infections.
In vivo	Ercalcitriol binds to vitamin D receptor (VDR), a nuclear receptor, activates the interaction between VDR and retinol X receptor (RXR) to form VDR/RXR/ cofactor complex, which binds to Vitamin D response elements in the promoter region of target genes to regulate gene transcription[3].
Synonyms	1α,25-Dihydroxy Vitamin D2

Chemical Properties

Molecular Weight	428.65
Formula	C₂₈H₄₄O₃
Cas No.	60133-18-8
Smiles	C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Relative Density.	1.066 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (104.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3329 mL	11.6645 mL	23.3291 mL	116.6453 mL
5 mM	0.4666 mL	2.3329 mL	4.6658 mL	23.3291 mL
10 mM	0.2333 mL	1.1665 mL	2.3329 mL	11.6645 mL
20 mM	0.1166 mL	0.5832 mL	1.1665 mL	5.8323 mL
50 mM	0.0467 mL	0.2333 mL	0.4666 mL	2.3329 mL
100 mM	0.0233 mL	0.1166 mL	0.2333 mL	1.1665 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.