Fluconazole hydrate [155347-36-7]
Référence B1226-5g
Conditionnement : 5g
Marque : APExBIO Technology
Fluconazole hydrate
Fluconazole (hydrate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 324.29 |
| Cas No. | 155347-36-7 |
| Formula | C13H14F2N6O2 |
| Solubility | ≥16.35 mg/mL in DMSO; ≥28.8 mg/mL in EtOH; ≥3.2 mg/mL in H2O with ultrasonic |
| Chemical Name | 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol hydrate |
| Canonical SMILES | OC(C41ncnc1)(C41ncnc1)c(ccc(F)c1)c1F.O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
| Cell lines | Pathogenic Candida species |
| Preparation method | The solubility of this compound in DMSO is ≥16.35mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
| Reacting condition | 100 mg/l |
| Applications | In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/1. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10−6 M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this. |
| References: [1]. Odds FC, Cheesman SL, Abbott AB. Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitro. J Antimicrob Chemother. 1986 Oct;18(4):473-8. PubMed PMID: 3021710. | |
Quality Control & MSDS
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Chemical structure
