Specifications

Product Data
Applications	IHC
Recommended Dilution	IHC: 25-100 Positive control: Human esophagus cancer Predicted cell location: Nucleus
Reactivities	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 662-677 amino acids of Human forkhead box P1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Predicted Protein Size	66 kDa
Gene Name	forkhead box P1
Database Link	NP_116071 Entrez Gene 108655 MouseEntrez Gene 297480 RatEntrez Gene 27086 Human UniProt ID Q9H334
Background	This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms	12CC4; hFKH1B; HSPC215; MFH; QRF1
Reference Data
Protein Families	Transcription Factors