Frizzled 5 Protein, Human, Recombinant (hFc)
Référence NB-64-60412-100ug
Conditionnement : 100ug
Marque : Neo Biotech
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Frizzled 5 Protein, Human, Recombinant (hFc)
(Synonyms: HFZ5, frizzled class receptor 5, C2orf31) Copy Product InfoSynonyms: HFZ5, frizzled class receptor 5, C2orf31
Catalog No. TMPY-05489 Copy Product Info
Frizzled 5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is Q13467.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Recombinant Human Frizzled 5 / FZD5 Protein (Fc Tag) at 2μg/mL (100μL/well) can bind pan-FZD antibody, Human IgG2 , the EC50 is 19-55 ng/mL. |
| Description | Frizzled 5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is Q13467. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | Q13467 |
| Construction | A DNA sequence encoding the human FZD5 (NP_003459.2) (Met1-Pro167) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ala 27 |
| Protein Purity | > 95 % as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | HFZ5, frizzled class receptor 5, C2orf31 |
| Research Background | Wnt signaling is involved in a variety of embryonic development processes of nonvertebrates and vertebrates, where it determines cell motility, cell polarity, differentiation, proliferation and apoptosis, as well as formation of neural synapses. Various homologs of the Wingless protein, termed WNT factors, represent key mediators and act through a receptor complex comprised of members of the Frizzled and low density lipoprotein-related receptors (LRP). 19 WNTs, 1 Frizzled, and 2 LRP proteins have been identified. Frizzled is a family of G protein-coupled receptor proteins consisting of a divergent signal peptide, a highly conserved extracellular cysteine-rich domain (CRD), a variable-length linker region, a seven-pass transmembrane domain, and a variable-length C-terminal tail.Frizzled 5 (FZD5) is believed to be the receptor for the Wnt5A ligand, and also interactions with Wnt1B, Wnt2B, and Wnt 7A functionally. Recent studies of WNT5A/Frizzled-5 signaling have revealed an unexpected and novel role in orchestrating adaptive immunity in response to microbial stimulation. In addition, FZD5 is also implicated in the survival of mature neurons in the parafascicular nucleus of the thalamus. |
| Molecular Weight | 42.7 kDa (predicted) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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HFZ-5HFZ 5
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Related Tags: Frizzled 5 Protein, Human, Recombinant (hFc) chemical structure | Frizzled 5 Protein, Human, Recombinant (hFc) molecular weight
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