GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. provided by RefSeq, Jul 2008
Protein Categories
Intracellular Proteins, Membrane Proteins, Nervous system Diseases
Protein Families
Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
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