Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Geranyl acetate [105-87-3]

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Référence NB-64-30018-25g

Conditionnement : 25g

Marque : Neo Biotech

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Geranyl acetate

Catalog No. T5607 Copy Product Info

Purity: 98.03%

Geranyl acetate is a monoterpene that has been found in C. sativa with diverse biological activities.

Geranyl acetate

Copy Product Info

Geranyl acetate is a monoterpene that has been found in C. sativa with diverse biological activities.

Cas No. 105-87-3

Batch Information

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Purity:98.03%

Appearance:Liquid

Color:Transparent

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Geranyl acetate is a monoterpene that has been found in C. sativa with diverse biological activities.
In vitro	Studies on the antifungal activity especially Microsporum gypsum, Trichophyton vercossum and Candida tropicalis showed that geranyl acetate, its epoxide and hydroperoxide derivatives have good antifungal action[1].Geranyl acetate exhibited significant anticancer activity against colo-205 cancer cell line with IC50 values of 30 μM . To find out the underlying mechanism, DAPI staining was carried out and it was observed that both the monoterpenes, geraniol and geranyl acetate, induced apoptosis in colo-205 cells. The apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expressions, indicative of mitochondrial apoptosis. Moreover, this monoterpenes could trigger DNA damage and G2/M cell cycle arrest in colo-205 cells[1].
Cell Research	The antiproliferative activity was determined by MTT assay. Apoptosis was assessed by DAPI staining and DNA damage was checked by comet assay. The cell cycle analysis was carried out by flow cytometry and protein expression was examined by western blotting.[1].

Chemical Properties

Molecular Weight	196.29
Formula	C₁₂H₂₀O₂
Cas No.	105-87-3
Smiles	CC(C)=CCCC(C)=CCOC(C)=O
Relative Density.	0.91

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1273.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0945 mL	25.4725 mL	50.9450 mL	254.7252 mL
5 mM	1.0189 mL	5.0945 mL	10.1890 mL	50.9450 mL
10 mM	0.5095 mL	2.5473 mL	5.0945 mL	25.4725 mL
20 mM	0.2547 mL	1.2736 mL	2.5473 mL	12.7363 mL
50 mM	0.1019 mL	0.5095 mL	1.0189 mL	5.0945 mL
100 mM	0.0509 mL	0.2547 mL	0.5095 mL	2.5473 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.