High density lipoprotein (human)

High density lipoprotein (human) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis.^[1][2]

One of the most important properties of HDL is its ability to induce NO production in endothelial cells, in part by acting on endothelial nitric oxide synthase (eNOS) through activation of surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K, and MAPK^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

High density lipoprotein improves multiple markers of glucose regulation and reduces inflammation in a mouse model of type 2 diabetes mellitus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liquid

Light yellow to yellow

[High density lipoprotein (human)]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jomard A, et al. High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential. Front Cardiovasc Med. 2020 Mar 31;7:39.  [Content Brief]

  [2]. de la Llera Moya M, et al. Inflammation modulates human HDL composition and function in vivo. Atherosclerosis. 2012;222(2):390-394.  [Content Brief]