Specifications

Product Data
Applications	IF, IHC, IP, WB
Recommended Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:5000-1:20000
Reactivities	Human (Predicted: Pig)
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 1 and 109 of HMGA2 (Uniprot ID#P52926)
Formulation	1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Predicted Protein Size	12 kDa
Gene Name	high mobility group AT-hook 2
Database Link	NP_003475 Entrez Gene 8091 Human UniProt ID P52926
Background	This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Synonyms	BABL; HMGI-C; HMGIC; LIPO; STQTL9
Note	Seq homology of immunogen across species: Pig (88%)
Reference Data
Protein Families	Druggable Genome