Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.

Human IgG4 (S228P) kappa, Isotype Control is often used as the experimental negative control. Human IgG4 (S228P) kappa, Isotype Control exhibits similar structure and biological properties as human immunoglobulin G4 (IgG4), but lacks specific antigen binding ability^[2].
Human IgG4 (S228P) kappa, Isotype Control (80 μg/mL, 1 h) exhibits no resistant effects against KRCV-1 and PBJV infection in MA-104 cell (Orilanolimab (HY-P99791) is used as the control in the experiment)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

• [1]. Gong Q, et al. Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation. MAbs. 2016;8(6):1098-1106.  [Content Brief]

  [2]. Shaw TM, et al., The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor. Nat Commun. 2024 Aug 7;15(1):6726.  [Content Brief]