Human IL8 (Interleukin 8) Sandwich ELISA Kit E0007133)

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	CXCL8
Gene ID:	3576
Uniprot ID:	IL8_HUMAN
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP.leading to impaired neutrophil endothelial transmigration and thus increased virulence.
Function	Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
Protein Name	Interleukin-8 Il-8 C-X-C Motif Chemokine 8 Chemokine C-X-C Motif Ligand 8 Emoctakin Granulocyte Chemotactic Protein 1 Gcp-1 Monocyte-Derived Neutrophil Chemotactic Factor Mdncf Monocyte-Derived Neutrophil-Activating Peptide Monap Neutrophil-Activating Protein 1 Nap-1 Protein 3-10c T-Cell Chemotactic Factor Cleaved Into - Mdncf-A Gcp/Il-8 Protein Iv Il8/Nap1 Form I - Interleukin-8 (Ala-Il-877 Gcp/Il-8 Protein Ii Il-8(1-77 Il8/Nap1 Form Ii Mdncf-B - Il-8(5-77 - Il-8(6-77 (Ser-Il-872 Gcp/Il-8 Protein I Il8/Nap1 Form Iii Lymphocyte-Derived Neutrophil-Activating Factor Lynap Mdncf-C Neutrophil-Activating Factor Naf - Il-8(7-77 Gcp/Il-8 Protein V Il8/Nap1 Form Iv - Il-8(8-77 Gcp/Il-8 Protein Vi Il8/Nap1 Form V - Il-8(9-77 Gcp/Il-8 Protein Iii Il8/Nap1 Form Vi
Database Links	Reactome: R-HSA-2559582 Reactome: R-HSA-375276 Reactome: R-HSA-380108 Reactome: R-HSA-380994 Reactome: R-HSA-418594 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807
Cellular Localisation	Secreted
Alternative ELISA Names	Interleukin-8 ELISA kit Il-8 ELISA kit C-X-C Motif Chemokine 8 ELISA kit Chemokine ELISA kit C-X-C Motif Ligand 8 ELISA kit Emoctakin ELISA kit Granulocyte Chemotactic Protein 1 ELISA kit Gcp-1 ELISA kit Monocyte-Derived Neutrophil Chemotactic Factor ELISA kit Mdncf ELISA kit Monocyte-Derived Neutrophil-Activating Peptide ELISA kit Monap ELISA kit Neutrophil-Activating Protein 1 ELISA kit Nap-1 ELISA kit Protein 3-10c ELISA kit T-Cell Chemotactic Factor Cleaved Into - Mdncf-A ELISA kit Gcp/Il-8 Protein Iv ELISA kit Il8/Nap1 Form I - Interleukin-8 ELISA kit (Ala-Il-877 ELISA kit Gcp/Il-8 Protein Ii ELISA kit Il-8(1-77 ELISA kit Il8/Nap1 Form Ii ELISA kit Mdncf-B - Il-8(5-77 - Il-8(6-77 ELISA kit (Ser-Il-872 ELISA kit Gcp/Il-8 Protein I ELISA kit Il8/Nap1 Form Iii ELISA kit Lymphocyte-Derived Neutrophil-Activating Factor ELISA kit Lynap ELISA kit Mdncf-C ELISA kit Neutrophil-Activating Factor ELISA kit Naf - Il-8(7-77 ELISA kit Gcp/Il-8 Protein V ELISA kit Il8/Nap1 Form Iv - Il-8(8-77 ELISA kit Gcp/Il-8 Protein Vi ELISA kit Il8/Nap1 Form V - Il-8(9-77 ELISA kit Gcp/Il-8 Protein Iii ELISA kit Il8/Nap1 Form Vi ELISA kit CXCL8 ELISA kit IL8 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance