Hydroxyurea is used as an inhibitor of DNA synthesis. As an anti-neoplastic, hydroxyurea inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.

Synonyms:
Carbamohydroxamic acid; N-Carbamoylhydroxylamine; N-Hydroxyurea; Biosupressin; Carbamohydroxamic Acid; Carbamoyl Oxime; Cytodrox; Droxia; HU; Hidrix; Hydrea; Hydreia; Hydroxycarbamide; Hydroxycarbamine; N-(Aminocarbonyl)hydroxylamine; Hydroxylurea; Hydura; Hydurea; Litaler; Litalir; N-Carbamoylhydroxylamine; NCI C04831; NSC 32065; Oxyurea; SK 22591; SQ 1089

CAS Number:
127-07-1

Molecular Formula:
CH4N2O2

Molecular Weight:
76.06

Purity:
97-103%

Appearance:
White to off-white crystalline powder

Solubility:
Soluble in water, practically insoluble in alcohol, soluble in hot alcohol.

Identification (IR):
Passes USP

Loss on Drying:
≤0.5%

Urea:
≤0.5%

Heavy Metals (Pb):
≤0.002%

Melting Point:
138-145°C

Related Substances:
≤0.2%

Chloride:
≤0.005%

Storage and Stability:
May be stored at 4°C. Stable for 12 months after receipt.