Kanamycin (sulfate) [25389-94-0]
Référence HY-16566A-1g
Conditionnement : 1g
Marque : MedChemExpress
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia.
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Kanamycin sulfate Chemical Structure
CAS No. : 25389-94-0
This product is a controlled substance and not for sale in your territory.
Based on 9 publication(s) in Google Scholar
Other Forms of Kanamycin sulfate:
- Kanamycin Obtenir un devis
Description |
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4]. |
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In Vitro |
Kanamycin sulfate (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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In Vivo |
Kanamycin sulfate (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Masse moléculaire |
582.58 |
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Formule |
C18H38N4O15S |
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CAS No. |
25389-94-0 |
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Unlabeled CAS |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OS(O)(=O)=O.O[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3(19)O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)(19)O[C@H](CN)[C@@H](O)[C@@H]1O |
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Structure Classification |
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Initial Source |
Streptomyces kanamyceticus |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvant et solubilité |
In Vitro:
H2O : ≥ 25 mg/mL (42.91 mM) DMSO : < 1 mg/mL (insoluble or slightly soluble) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 1.7165 mL | 8.5825 mL | 17.1650 mL | 42.9126 mL |
5 mM | 0.3433 mL | 1.7165 mL | 3.4330 mL | 8.5825 mL | |
10 mM | 0.1717 mL | 0.8583 mL | 1.7165 mL | 4.2913 mL | |
15 mM | 0.1144 mL | 0.5722 mL | 1.1443 mL | 2.8608 mL | |
20 mM | 0.0858 mL | 0.4291 mL | 0.8583 mL | 2.1456 mL | |
25 mM | 0.0687 mL | 0.3433 mL | 0.6866 mL | 1.7165 mL | |
30 mM | 0.0572 mL | 0.2861 mL | 0.5722 mL | 1.4304 mL | |
40 mM | 0.0429 mL | 0.2146 mL | 0.4291 mL | 1.0728 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Kanamycin sulfate Related Classifications
- Anti-infection
- Bacterial Antibiotic