Ki67 antibody [SP6]
Référence GTX16667-500ul
Conditionnement : 500ul
Marque : Genetex
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
![Anti-Ki67 antibody [SP6] used in IHC (Paraffin sections) (IHC-P). GTX16667](http://www.genetex.com/templates/default/js/lightbox/images/loading.gif "Anti-Ki67 antibody [SP6] used in IHC (Paraffin sections) (IHC-P). GTX16667")
Host | Rabbit |
|---|---|
Clonality | Monoclonal |
Clone Name | SP6 |
Isotype | IgG |
Application | WB, ICC/IF, IHC-P, IHC-Fr, FACS, IHC |
Reactivity | Human, Mouse, Rat, Chicken, Pig |
| Package | 500 μl |
Datasheet File View product citations for antibody GTX16667 on CiteAb
PRODUCT
Summary
Ki67 antibody recognizes Ki67 antigen, a nuclear nonhistone protein with a predicted molecular weight of 359 kDa. Ki67 is present during the active phases of the cell cycle and is used clinically as a proliferation marker. Ki67 antibody is used extensively in immunohistochemistry to assess the grade or apparent aggressiveness of various malignancies.
APPLICATION
Application Note
IHC-P: 1:100-1:1000. Staining of formalin-fixed tissues is required by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. WB: 1/200. Predicted molecular weight: 359 kDa. Not tested in other applications
Calculated MW
359 kDa. ( Note )
Positive Control
Tonsil
PROPERTIES
Form
Liquid
Buffer
Tissue culture supernatant, PBS, BSA
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Antigen Species
Human
Purification
Tissue culture supernatant
Conjugation
Unconjugated
RRID
AB_422351
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
marker of proliferation Ki-67 , KIA , MIB- , MIB-1 , PPP1R105
Cellular Localization
Nucleus , Nucleolus
Background
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
Database
DATA IMAGES
| | GTX16667 IHC-P Image Ki67 antibody [SP6] detects Ki67 protein at nucleus in human cervical metaplasia (left) and carcinoma (right) by immunohistochemical analysis. |
| | GTX16667 IHC-P ImageKi67 antibody [SP6] detects Ki67 protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human breast carcinoma.Ki67 stained by Ki67 antibody [SP6] (GTX16667) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min |
| | GTX16667 IHC-P ImageKi67 antibody [SP6] detects Ki67 protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human colon cancer.Ki67 stained by Ki67 antibody [SP6] (GTX16667) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min |
| | GTX16667 IHC-P ImageKi67 antibody [SP6] detects Ki67 protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human endometrial carcinoma.Ki67 stained by Ki67 antibody [SP6] (GTX16667) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min |
| | GTX16667 IHC-P ImageKi67 antibody [SP6] detects Ki67 protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human ovarian cancer.Ki67 stained by Ki67 antibody [SP6] (GTX16667) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min |
| | GTX16667 IHC-P ImageKi67 antibody [SP6] detects Ki67 protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human cervical carcinoma.Ki67 stained by Ki67 antibody [SP6] (GTX16667) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min |
| | GTX16667 IHC-P ImageKi67 antibody [SP6] detects Ki67 protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded human colon cancer.Ki67 stained by Ki67 antibody [SP6] (GTX16667) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min |
| | GTX16667 IHC-P ImageThe data was published in the 2021 in Fujita Med J. PMID: 35111543 |
| | GTX16667 IHC-P ImageThe data was published in the 2021 in Fujita Med J. PMID: 35111543 |
| | GTX16667 IHC ImageThe data was published in the journal Nat Commun in 2016. PMID: 26965827 |
| | GTX16667 IHC-P ImageThe data was published in the journal Cell Death Dis in 2019. PMID: 31659152 |
| | GTX16667 IHC-P ImageThe data was published in the journal Cell Death Dis in 2019. PMID: 31659152 |
| | GTX16667 IHC-P ImageThe data was published in the journal Sci Rep in 2017. PMID: 28785010 |
| | GTX16667 IHC-P ImageThe data was published in the journal PLoS One in 2015. PMID: 25747583 |
| | GTX16667 IHC-P ImageThe data was published in the journal Front Oncol in 2020.PMID: 32426268 |
| | GTX16667 IHC-P ImageThe data was published in the journal Nat Commun in 2016.PMID: 27187615 |
| | GTX16667 IHC-P ImageThe data was published in the journal Nat Commun in 2016.PMID: 27187615 |
| | GTX16667 IHC-P ImageThe data was published in the journal BMC Cancer in 2019.PMID: 30606143 |
| | GTX16667 IHC-P ImageThe data was published in the journal Nat Commun in 2016.PMID: 27187615 |
| | GTX16667 IHC ImageThe data was published in the journal Nat Commun in 2016. PMID: 26965827 |
| | GTX16667 IHC ImageThe data was published in the journal Nat Commun in 2016. PMID: 26965827 |
Application Reference
Idelfonso-Garc?a OG et al. Antioxidants (Basel) 2024; 13 (3) Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver.
OG Idelfonso-Garc?a et al. Antioxidants? 2024; 13 (1) : 257 Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver
Application : IHC-P
Blatt EB et al. Oncogene 2023; 42 (30) : 2347-2359 Critical role of antioxidant programs in enzalutamide-resistant prostate cancer.
Hendricks E et al. Cell Rep 2023; 42 (8) : 112983 The C9ORF72 repeat expansion alters neurodevelopment.
Kim GY et al. Animals (Basel) 2023; 13 (18) Comparative Analysis of Porcine Adipose- and Wharton's Jelly-Derived Mesenchymal Stem Cells.
Submit a Reference REVIEW
Application Reference
Idelfonso-Garc?a OG et al. Antioxidants (Basel) 2024; 13 (3) Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver.
OG Idelfonso-Garc?a et al. Antioxidants? 2024; 13 (1):257 Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver
Application : IHC-P
Blatt EB et al. Oncogene 2023; 42 (30):2347-2359 Critical role of antioxidant programs in enzalutamide-resistant prostate cancer.
Hendricks E et al. Cell Rep 2023; 42 (8):112983 The C9ORF72 repeat expansion alters neurodevelopment.
Kim GY et al. Animals (Basel) 2023; 13 (18) Comparative Analysis of Porcine Adipose- and Wharton's Jelly-Derived Mesenchymal Stem Cells.
CE Antal et al. Nat Commun 2023; 14 (1):5195 A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
Application : IHC-P
Reactivity : Mouse
Liao YC et al. Mol Ther Nucleic Acids 2023; 33:351-366 Tumor targeting and therapeutic assessments of RNA nanoparticles carrying α9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers.
Zhang N et al. Nat Aging 2023; 3 (2):185-201 Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.
Chen A et al. Front Mol Neurosci 2023; 16:1151162
Takasago T et al. PLoS One 2023; 18 (3):e0283822 Anti-tumor necrosis factor-alpha monoclonal antibody suppresses colorectal cancer growth in an orthotopic transplant mouse model.
Application : IHC
Feng XF et al. Front Cell Neurosci 2023; 17:1125412 Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes.
Application : IHC
Reactivity : Rat
Ono M et al. Discov Oncol 2023; 14 (1):9 Anti-tumor effect of Wasabi component, 6-(methylsulfinyl) hexyl isothiocyanate, against endometrial carcinoma cells.
Hu Q et al. EMBO J 2023; 42 (1):e110937 Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice.
Son J et al. Nat Commun 2023; 14 (1):558 Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure.
Application : IHC-Fr
Reactivity : Mouse
Taha M et al. Int J Mol Sci 2023; 24 (1) Dexmedetomidine Attenuates Methotrexate-Induced Neurotoxicity and Memory Deficits in Rats through Improving Hippocampal Neurogenesis: The Role of miR-15a/ROCK-1/ERK1/2/CREB/BDNF Pathway Modulation.
Application : IHC-P
Reactivity : Rat
Sun Y et al. Theranostics 2022; 12 (17):7307-7318 Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling.
Application : IHC-Fr
Reactivity : Mouse
Giraldo E et al. Cells 2022; 11 (20) Transplantation of Human-Fetal-Spinal-Cord-Derived NPCs Primed with a Polyglutamate-Conjugated Rho/Rock Inhibitor in Acute Spinal Cord Injury.
Application : ICC/IF, IHC-Fr
Reactivity : Human
Bartolom? A et al. Diabetes 2022; 71 (11):2395-2401 An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition.
Application : IHC-P
Reactivity : Mouse
Weber AA et al. Nat Commun 2022; 13 (1):4346 Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice.
Application : IHC-P
Reactivity : Mouse
Polat R et al. J Clin Res Pediatr Endocrinol 2022; 14 (4):415-421 Effect of Propolis on Precocious Puberty in Female Rats.
Application : IHC-P
Reactivity : Rat
Zhang Y et al. iScience 2022; 25 (10):105115 RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11.
Elsukary AE et al. Neurotox Res 2022; 40 (5):1427-1439
Chao X et al. Am J Pathol 2022; 192 (1):87-103 Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Cuenca-Ortol? I et al. Biomedicines 2022; 10 (11) A Strategy for Magnetic and Electric Stimulation to Enhance Proliferation and Differentiation of NPCs Seeded over PLA Electrospun Membranes.
Yuxia Sun et al. Adv Sci (Weinh) 2022; 9 (3):e2103065 Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.
Application : IHC-Fr
Reactivity : Mouse
Aneta Przepiorski et al. Stem Cell Res Ther 2022; 13 (1):76 Modeling oxidative injury response in human kidney organoids.
Application : IHC-P
Reactivity : Human
Minsung Kang et al. Front Oncol 2022; 12:835833 PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer.
Application : WB
Na Zhang et al. Int J Mol Sci 2022; 23 (7) Dual Inhibition of H3K9me2 and H3K27me3 Promotes Tumor Cell Senescence without Triggering the Secretion of SASP.
Application : WB
Maria Khan et al. Oncol Rep 2022; 47 (6) Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local anti?tumor immunity in the tumor stroma.
Application : IHC-P
Reactivity : Mouse
Endo T et al. NPJ Regen Med 2022; 7 (1):12 Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury.
Application : IHC-Fr
Baglieri J et al. Am J Pathol 2021; 191 (9):1564-1579 Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice.
Application : IHC-P
Reactivity : Mouse
Cheng TC et al. J Food Drug Anal 2021; 29 (4):622-637 Curcumin-induced antitumor effects on triple-negative breast cancer patient-derived xenograft tumor mice through inhibiting salt-induced kinase-3 protein.
Application : IHC-P
Reactivity : Mouse
Naoko Uga et al. Fujita Med J 2021; 7 (2):41-49 A new murine ileostomy model: recycling stool prevents intestinal atrophy in the distal side of ileostomy.
Application : IHC-P
Reactivity : Rat
Kuo-Hao Ho et al. Neurotherapeutics 2021; 18 (2):1371-1392 Guanabenz Sensitizes Glioblastoma Cells to Sunitinib by Inhibiting GADD34-Mediated Autophagic Signaling.
Application : WB, ICC/IF
Reactivity : Human
Qiao Jin et al. Front Oncol 2021; 11:572585 lncRNA MIR22HG-Derived miR-22-5p Enhances the Radiosensitivity of Hepatocellular Carcinoma by Increasing Histone Acetylation Through the Inhibition of HDAC2 Activity.
Application : IHC-P
Reactivity : Human
Jose Luis Herrera et al. J Vasc Res 2021; 58 (4):252-266 R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
Reactivity : Mouse
Cancan Lyu et al. JCI Insight 2021; 6 (18) Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy.
Application : IHC
Reactivity : Mouse
Cheng WJ et al. Front Pharmacol 2021; 12:762829 Astragalus mongholicus Bunge Water Extract Exhibits Anti-inflammatory Effects in Human Neutrophils and Alleviates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice.
Karkampouna S et al. Cells 2021; 10 (12) Oncofetal Protein CRIPTO Is Involved in Wound Healing and Fibrogenesis in the Regenerating Liver and Is Associated with the Initial Stages of Cardiac Fibrosis.
Karkampouna S et al. Cells 2021; 10 (12):3325 Oncofetal Protein CRIPTO Is Involved in Wound Healing and Fibrogenesis in the Regenerating Liver and Is Associated with the Initial Stages of Cardiac Fibrosis.
Application : IHC-P
Reactivity : Human
Gerossier E et al. Arthritis Res Ther 2021; 23 (1):289 Cenerimod, a selective S1P1 receptor modulator, improves organ-specific disease outcomes in animal models of Sj?gren's syndrome.
Application : IHC-P
Reactivity : Mouse
Do M et al. Mol Cancer Ther 2021; (Epub) A FZD7-specific antibody-drug conjugate induces ovarian tumor regression in preclinical models.
Application : IHC-P
Reactivity : Human
Heinrich A et al. Cell Rep 2021; 37 (4):109885 Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis.
Application : IHC-Fr
Xiang Y et al. Vet Res 2021; 52 (1):110 Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/β-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells.
Reactivity : Chicken
Molinas A et al. Cells 2021; 10 (9) The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis.
Application : IHC-Fr
Reactivity : Mouse
Walgrave H et al. Cell Stem Cell 2021; Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Reactivity : Mouse
Liu H et al. Cell Death Dis 2021; 12 (6):610 G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production.
Application : IHC-P
Reactivity : Human
Lee SR et al. Cell Commun Signal 2021; 19 (1):42 Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer.
Application : IHC-P
Reactivity : Mouse
Escudero-Hern?ndez C et al. Cell Mol Gastroenterol Hepatol 2021; 12 (2):665-687 Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease.
Application : IHC-P
Reactivity : Human
Guillermin O et al. EMBO J 2021; 40 (13):e105770 Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration.
Application : IHC-P
Reactivity : Mouse
Xiao J et al. Front Oncol 2021; 11:652206 LINC00467 Promotes Tumor Progression via Regulation of the NF-kb Signal Axis in Bladder Cancer.
Application : IHC-P
Reactivity : Human
Jin MH et al. Gastric Cancer 2021; WEE1 inhibition reverses trastuzumab resistance in HER2-positive cancers.
Taki K et al. PLoS One 2021; 16 (3):e0248065 Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet.
Application : IHC-P
Reactivity : Mouse
Zhang N et al. Int J Mol Sci 2021; 22 (2) The Interaction of the Senescent and Adjacent Breast Cancer Cells Promotes the Metastasis of Heterogeneous Breast Cancer Cells through Notch Signaling.
Reactivity : Human
Changchien CY et al. Cancer Sci 2021; 112 (2):781-791 Distinct JNK/VEGFR signaling on angiogenesis of breast cancer-associated pleural fluid based on hormone receptor status.
Application : ICC/IF
Reactivity : Human
Andrew H Smith et al. JVS Vasc Sci 2020; 1:136-150 Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury.
Application : WB, IHC-P
Reactivity : Mouse
Zhanwang Wang et al. Am J Cancer Res 2020; 10 (11):3686-3704 Long non-coding RNA FOXD1-AS1 promotes the progression and glycolysis of nasopharyngeal carcinoma by sustaining FOXD1 expression.
Application : IHC-P
Reactivity : Human
Yen-Yun Wang et al. Cancers (Basel) 2020; 12 (12) Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages.
Application : WB
Reactivity : Human
Masaki S et al. Int J Exp Pathol 2020; 101 (5):162-170 Fatty change of the liver microenvironment influences the metastatic potential of colorectal cancer.
Low HY et al. Cancers (Basel) 2020; 12 (6) Reciprocal Regulation Between Indoleamine 2,3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells.
Zhang G et al. Oncol Lett 2020; 19 (6):3871-3880 Survivin expression as an independent predictor of overall survival in malignant peritoneal mesothelioma.
Gong L et al. Front Oncol 2020; 10:461
Karkampouna S et al. Cancers (Basel) 2020; 12 (12) Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures.
Application : IHC-P
Reactivity : Mouse
Xiao M et al. Clin Transl Med 2020; 10 (8):e241 MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Application : IHC-P
Reactivity : Human
Mennillo E et al. Cell Mol Gastroenterol Hepatol 2020; 10 (1):133-147 NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult.
McCarthy N et al. Cell Stem Cell 2020; 26 (3):391-402.e5 Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.
Sun Z et al. Life Sci 2020; 263:118672
Application : ICC/IF
Reactivity : Mouse
Martinikova AS et al. Cells 2020; 9 (9) Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.
Application : IHC-P
Reactivity : Mouse
Hasegawa K et al. FEBS J 2020; (Epub) Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor.
Application : WB
Reactivity : Mouse
Wei J et al. J Cell Mol Med 2020; 24 (19):11366-11380
Application : IHC-P
Reactivity : Human
Wang B et al. J Exp Clin Cancer Res 2020; 39 (1):170 KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
Application : IHC-P
Reactivity : Human
Cheung P et al. Cell Stem Cell 2020; 27 (4):590-604.e9 Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.
Application : IHC-P
Reactivity : Mouse
Huang CT et al. Neurochem Int 2020; 140:104827 Melatonin reduces neuropathic pain behavior and glial activation through MT2 melatonin receptor modulation in a rat model of lysophosphatidylcholine-induced demyelination neuropathy.
Application : IHC-Fr
Reactivity : Rat
He S et al. Front Pharmacol 2020; 11:1099 Dioscin Promotes Prostate Cancer Cell Apoptosis and Inhibits Cell Invasion by Increasing SHP1 Phosphorylation and Suppressing the Subsequent MAPK Signaling Pathway.
Application : IHC-P
Reactivity : Human
Chiu CF et al. Biomed Pharmacother 2020; 128:110309 The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer.
Application : IHC-P
Reactivity : Mouse
Gong L et al. Cancer Cell Int 2020; 20:194
Application : IHC-P
Reactivity : Mouse
Lin C et al. Cell Death Differ 2020; 27 (9):2697-2709 Arginine hypomethylation-mediated proteasomal degradation of histone H4-an early biomarker of cellular senescence.
Application : WB
Hosono K et al. Biomed Pharmacother 2020; 128:110264 Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis.
Application : IHC-P
Reactivity : Mouse
Heinrich A et al. Cell Rep 2020; 31 (2):107513 Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis.
Application : IHC-Fr
Reactivity : Mouse
Nogimura D et al. FASEB J 2020; 34 (4):5715-5723 Prolyl-hydroxyproline, a collagen-derived dipeptide, enhances hippocampal cell proliferation, which leads to antidepressant-like effects in mice.
Application : IHC-Fr
Reactivity : Mouse
Lebreton F et al. Am J Transplant 2020; (Epub) Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model.
Lu J et al. Exp Cell Res 2020; 387 (1):111752 MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
Application : IHC-P
Reactivity : Human
Wang YY et al. Biochem Pharmacol 2020; 171:113713 Orabase-formulated gentian violet effectively improved oral potentially malignant disorder in vitro and in vivo.
Application : WB
Reactivity : Human
Liang S et al. Gastroenterology 2019; 156 (4):1156-1172.e6 NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
Lee SR et al. BMC Cancer 2019; 19 (1):6 Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation.
Burocziova M et al. Cell Death Dis 2019; 10 (11):818 Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.
Application : WB, IHC-P
Reactivity : Mouse
Ng WH et al. Int J Mol Sci 2019; 20 (22) Human Wharton's Jelly-Derived Mesenchymal Stem Cells Minimally Improve the Growth Kinetics and Cardiomyocyte Differentiation of Aged Murine Cardiac c-kit Cells in In Vitro without Rejuvenating Effect.
Application : ICC/IF
Reactivity : Mouse
Zhou Y et al. J Control Release 2019; 316:93-104 Injectable extracellular vesicle-released self-assembling peptide nanofiber hydrogel as an enhanced cell-free therapy for tissue regeneration.
Application : IHC-Fr
Reactivity : Mouse
Babos KN et al. Cell Stem Cell 2019; 25 (4):486-500.e9 Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming.
Application : FACS
Reactivity : Mouse
Liang Q et al. Cell Rep 2019; 28 (8):2004-2011.e4 SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.
Application : IHC-P
Reactivity : Mouse
Lauzier A et al. Sci Rep 2019; 9 (1):11316 Colorectal cancer cells respond differentially to autophagy inhibition in vivo.
Application : IHC-P
Reactivity : Chicken
Xie C et al. Biomed Pharmacother 2019; 118:109270 Targeting TRPV1 on cellular plasticity regulated by Ovol 2 and Zeb 1 in hepatocellular carcinoma.
Application : IHC-P
Reactivity : Mouse
Mizushige T et al. J Nutr Sci Vitaminol (Tokyo) 2019; 65 (3):251-257 Ginger-Degraded Collagen Hydrolysate Exhibits Antidepressant Activity in Mice.
Application : IHC
Reactivity : Mouse
Wang F et al. J Exp Clin Cancer Res 2019; 38 (1):286 CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis.
Zhu Y et al. Oncogene 2019; (Epub)
Application : IHC-P
Reactivity : Human
Li M et al. Cancer Res 2019; (Epub) Transketolase deficiency protects the liver from DNA damage by increasing levels of ribose 5-phosphate and nucleotides.
Application : ICC/IF
Liu J et al. Mol Med Rep 2019; 20 (1):33-40 miR-338-3p inhibits A549 lung cancer cell proliferation and invasion by targeting AKT and β-catenin signaling pathways.
Application : ICC/IF
Reactivity : Human
Koffler J et al. Nat Med 2019; 25 (2):263-269 Biomimetic 3D-printed scaffolds for spinal cord injury repair.
Application : IHC-Fr
Reactivity : Rat
Udjus C et al. Am J Physiol Lung Cell Mol Physiol 2019; 316 (6):L999-L1012 Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension.
Application : ICC/IF
Reactivity : Mouse
Wiggins KA et al. Aging Cell 2019; 18 (3):e12946 IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.
Application : IHC-P
Reactivity : Mouse
Perez-Dominguez M et al. Neural Regen Res 2019; 14 (5):817-825 The detrimental effects of lipopolysaccharide-induced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response.
Application : IHC
Reactivity : Mouse
Lien BV et al. Exp Neurol 2019; 314:46-57 Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord.
Kozareva DA et al. Behav Brain Res 2019; 360:36-50 TLX knockdown in the dorsal dentate gyrus of juvenile rats differentially affects adolescent and adult behaviour.
Application : IHC-Fr
Reactivity : Rat
Lian Zheng et al. Oncol Res 2018; 26 (3):483-494 Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis by Epigenetically Reactivating the p53 Pathway.
Application : IHC-P
Reactivity : Mouse
Rehrauer H et al. Oncogene 2018; 37 (20):2645-2659 How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations.
Thompson JM et al. Mol Cancer Ther 2018; 17 (8):1781-1792 Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism.
Nam AR et al. Cancer Res Treat 2018; (Epub) Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer.
Application : IHC-P
Lee J et al. J Biomed Mater Res B Appl Biomater 2018; (Epub) Treatment of intractable oral ulceration with an oral mucosa equivalent.
Application : IHC-P
Reactivity : Rat
Wei J et al. Cancer Med 2018; 7 (12):6247-6257 long non-coding rna h19 promotes tdrg1 expression and * resistance by sequestering mirna-106b-5p in seminoma.
Application : IHC
Reactivity : Human
Yuan WC et al. Nat Commun 2018; 9 (1):4834 NUAK2 is a critical YAP target in liver cancer.
Application : IHC-P
Reactivity : Human
Nam AR et al. Cancer Res Treat 2018; (Epub) jab1 silencing inhibits proliferation and sensitizes to * in biliary tract cancer.
Application : IHC-P
Reactivity : Mouse
Beaudry K et al. J Cell Physiol 2018; (Epub) Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis.
Application : IHC-P
Reactivity : Mouse
Yrlid U et al. J Leukoc Biol 2018; (Epub) Endothelial repair is dependent on CD11c+ leukocytes to establish regrowing endothelial sheets with high cellular density.
Application : IHC
Reactivity : Mouse
Biehs B et al. Nature 2018; 562 (7727):429-433. A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.
Application : IHC-P
Reactivity : Mouse
Min A et al. Mol Cancer Ther 2018; (Epub) Androgen receptor inhibitor enhances the anti-tumor effect of PARP inhibitor in breast cancer cells by modulating DNA damage response.
Application : IHC-P
Reactivity : Human
Fang CC et al. Sci Rep 2018; 8 (1):13802 AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage.
Application : IHC-P
Reactivity : Mouse
Wu CC et al. Biomaterials 2018; 185:142-154 Synthetic α5β1 integrin ligand PHSRN is proangiogenic and neuroprotective in cerebral ischemic stroke.
Application : IHC-Fr
Reactivity : Rat
Wang SW et al. Neurosci Res 2018; (Epub) Radioprotective effect of epimedium on neurogenesis and * after acute radiation exposure.
Application : IHC-P
Reactivity : Mouse
Lin JH et al. Breast Cancer Res Treat 2018; (Epub) oestrogen receptor-regulated glutathione s-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers * resistance on breast cancer cells.
Application : IHC-Fr
Reactivity : Human
Gomora MJ et al. Endocr Connect 2018; (Epub) Sexual steroid hormone receptors profiles in ovarian carcinoma in Mexican women.
Application : IHC-P
Reactivity : Human
Nguyen QH et al. Nat Commun 2018; 9 (1):2028 Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.
Application : IHC-P
Reactivity : Human
Schlereth K et al. Elife 2018; 7 The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium.
Application : IHC-Fr
Reactivity : Mouse
Hsieh FY et al. Biomaterials 2018; (Epub) Non-viral delivery of an optogenetic tool into cells with self-healing hydrogel.
Application : ICC/IF
Reactivity : Mouse
Min A. et al. Cancer Letters 2018; (Epub) cyclin e overexpression confers resistance to the cdk4/6 specific inhibitor * in gastric cancer cells.
Application : IHC-P
Reactivity : Human
Li B et al. Acta Pharmacol Sin 2018; (Epub) TIGAR knockdown enhanced the anticancer effect of aescin via regulating autophagy and apoptosis in colorectal cancer cells.
Application : IHC-P
Reactivity : Human
Eckhardt BL et al. PLoS One 2018; 13 (5):e0195932 Clinically relevant inflammatory breast cancer patient-derived xenograft-derived ex vivo model for evaluation of tumor-specific therapies.
Application : IHC-P
Cheng YC et al. Cell Physiol Biochem 2018; 45 (2):819-831 Interference with PSMB4 Expression Exerts an Anti-Tumor Effect by Decreasing the Invasion and Proliferation of Human Glioblastoma Cells.
Application : WB, IHC-Fr
Reactivity : Human
Vendramini-Costa DB et al. Carcinogenesis 2017; 38 (1):51-63 Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis.
Itoh M et al. Oncotarget 2017; 8 (54):92157-92170 The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells.
Application : IHC-P
Reactivity : Human
Qian L et al. Cytotechnology 2017; (Epub) Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway.
Application : IHC-P
Reactivity : Human
Todoric J et al. Cancer Cell 2017; 32 (6):824-839.e8 Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Application : IHC-P
Reactivity : Mouse
Bi T et al. Cytotechnology 2017; (Epub) * synergistically enhances antitumor activity of * in gallbladder cancer via the pi3k/akt/erk pathway.
Application : IHC-P
Reactivity : Human
Cheng ZF et al. Am J Physiol Gastrointest Liver Physiol 2017;:ajpgi.00240.2017 Rack1 function in intestinal epithelia: regulating crypt cell proliferation and regeneration and promoting differentiation and apoptosis.
Application : IHC-Fr
Reactivity : Mouse
Wang BY et al. Nanomaterials (Basel) 2017; 7 (9) Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles.
Application : IHC-P
Reactivity : Mouse
Miura A et al. Biosci Biotechnol Biochem 2017;:43107 Effects of pharmacological inhibition of plasminogen binding on liver regeneration in rats.
Application : IHC-P
Reactivity : Rat
Han HW et al. Colloids Surf B Biointerfaces 2017; 158:527-538 Chitosan derived co-spheroids of neural stem cells and mesenchymal stem cells for neural regeneration.
Application : ICC/IF
Reactivity : Mouse
Chen HC et al. Sci Rep 2017; 7 (1):7372 Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.
Application : IHC-P
Reactivity : Mouse
Kijani S et al. Physiol Rep 2017; 5 (14) Intimal hyperplasia induced by vascular intervention causes lipoprotein retention and accelerated atherosclerosis.
Application : IHC-Fr
Reactivity : Mouse
Chen S et al. Proc Natl Acad Sci U S A 2017; 114 (8):E1432-E1440 Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
Application : IHC-P
Reactivity : Mouse
Tang FR et al. Physiol Behav 2017; 175:37-46 Radioprotective effect of ursolic acid in radiation-induced impairment of neurogenesis, learning and memory in adolescent BALB/c mouse.
Application : IHC-Fr
Reactivity : Mouse
Osanai K et al. Hum Cell 2017; (Epub) *, a selective mt1/mt2 receptor agonist, suppresses the proliferation and invasiveness of endometrial cancer cells.
Wang LT et al. Oncogene 2017; (Epub) Transcription factor SPZ1 promotes TWIST-mediated epithelial-mesenchymal transition and oncogenesis in human liver cancer.
Application : WB
Reactivity : Human
Nakamura Y et al. Indian J Pathol Microbiol 2017; 60 (1):33-37 Serotonin receptor 4 (5-hydroxytryptamine receptor Type 4) regulates expression of estrogen receptor beta and cell migration in hormone-naive prostate cancer.
Application : IHC-P
Reactivity : Human
Yuan B et al. Oncotarget 2016; 7 (27):42585-42597 Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer.
Nesset CK et al. Fibrogenesis Tissue Repair 2016; 9:5 Age-dependent development of liver fibrosis in Glmp (gt/gt) mice.
Application : IHC-P
Reactivity : Mouse
Murai K et al. Nat Commun 2016; 7:10965 The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.
Application : IHC-P
Reactivity : Mouse
Liu Y et al. Technol Cancer Res Treat 2016; 15 (3):487-97 Effects of Oxymatrine on the Proliferation and Apoptosis of Human Hepatoma Carcinoma Cells.
Application : IHC-P
Reactivity : Mouse
Cheng YY et al. EMBO Mol Med 2016; (Epub) Reprogramming-derived gene cocktail increases cardiomyocyte proliferation for heart regeneration.
Application : ICC/IF
Reactivity : Mouse
Aguilera-Castrejon A et al. Neurochem Res 2016; (Epub) Improved Proliferative Capacity of NP-Like Cells Derived from Human Mesenchymal Stromal Cells and Neuronal Transdifferentiation by Small Molecules.
Application : ICC/IF
Reactivity : Human
Shan L et al. Sci Rep 2016; 6:36037 mTOR Overactivation in Mesenchymal cells Aggravates CCl4- Induced liver Fibrosis.
Application : IHC-P
Reactivity : Mouse
Liu Y et al. Apoptosis 2016; (Epub) oxymatrine synergistically enhances antitumor activity of * in colon carcinoma through pi3k/akt/mtor pathway.
Application : IHC-P
Reactivity : Mouse
Lin HH et al. J. Mater. Chem. B. 2016; (Epub) Preparation and characterization of a biodegradable polyurethane hydrogel and the hybrid gel with soy protein for 3D cell-laden bioprinting.
Application : IHC-P
Reactivity : Mouse
Gabriela FG et al. J CANCER 2016; 7 (12):1632-1644 Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer.
Application : IHC-P
Reactivity : Mouse
Xie C et al. Onco Targets Ther 2016; 9:4005-13 Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2-p53 signaling.
Application : WB
Reactivity : Human
Liou AT et al. Sci Rep. 2016; 6:31151 A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71.
Application : IHC-P
Reactivity : Mouse
Liu X et al. Drug Chem Toxicol 2016;:43110 possible role of mitochondrial injury in caulis aristolochia manshuriensis-induced chronic * nephropathy.
Application : IHC-P
Reactivity : Rat
de Jong PR et al. Nat Commun 2016; 7:11551 ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.
Application : IHC-P
Reactivity : Mouse
Chuang HM et al. Front Pharmacol 2016; 7:112 The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration.
Application : IHC-P
Reactivity : Rat
Nam AR et al. Mol Cancer Ther 2016; (Epub) Src as a therapeutic target in biliary tract cancer.
Application : IHC-P
Reactivity : Human
Gan Y et al. Cancer Biol Ther 2016;:43110 tdrg1 regulates chemosensitivity of seminoma tcam-2 cells to * via pi3k/akt/mtor signaling pathway and mitochondria-mediated apoptotic pathway.
Application : IHC-P
Reactivity : Human
Cheng YC et al. J. Nutr. Biochem. 2016; 33:63-72 Caffeine Suppresses the Progression of Human Glioblastoma via Cathepsin B and MAPK Signaling Pathway.
Application : WB
Reactivity : Human
Tandon M et al. PLoS One 2015; 10 (3):e0119346 SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest.
Application : IHC-P
Reactivity : Human
Lan T et al. PLoS One 2015; 10 (7):e0129743 Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.
Application : IHC-P
Reactivity : Mouse
Liu XY et al. Am J Cancer Res 2015; 5 (10):3015-29 MicroRNA-101-3p suppresses cell proliferation, invasion and enhances chemotherapeutic sensitivity in salivary gland adenoid cystic carcinoma by targeting Pim-1.
Application : IHC-P
Reactivity : Mouse
Antonucci L et al. Proc Natl Acad Sci U S A 2015; 112 (45):E6166-74 Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress.
Abraham S et al. Nat Commun 2015; 6 (Epub):7286 A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
Application : IHC
Reactivity : Human
Kijani S et al. PLoS One 2015; 10 (3):e0119499 Filter-Dense Multicolor Microscopy.
Reactivity : Mouse
Taniguchi K et al. Nature 2015; 519 (7541):57-62 A gp130-Src-YAP module links inflammation to epithelial regeneration.
Application : IHC-P
Reactivity : Mouse
Wu X et al. Proc Natl Acad Sci U S A 2014; 111 (38):13870-5 Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Application : IHC-P
Reactivity : Mouse
Nakagawa H et al. Proc Natl Acad Sci U S A 2014; 111 (3):1090-5 Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.
Application : IHC-P
Reactivity : Human
Murai K et al. Proc Natl Acad Sci U S A 2014; 111 (25):9115-20 Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model.
Application : ICC/IF
Reactivity : Mouse
Wang K et al. Immunity 2014; 41 (6):1052-63 Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
Application : IHC
Reactivity : Mouse
Yueh MF et al. Proc Natl Acad Sci U S A 2014; 111 (48):17200-5 The commonly used antimicrobial additive triclosan is a liver tumor promoter.
Application : IHC
Reactivity : Mouse
Li KC et al. Mol Cancer 2014; 13:172 Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.
Application : IHC-P
Reactivity : Human
Nakagawa H et al. Cancer Cell 2014; 26 (3):331-43 ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development.
Application : WB
Reactivity : Mouse
Chen S et al. Proc Natl Acad Sci U S A 2013; 110 (47):19143-8 intestinal glucuronidation protects against chemotherapy-induced toxicity by * (cpt-11).
Application : IHC-Fr
Reactivity : Mouse
Corbitt N et al. Am J Pathol 2013; 182 (1):180-91 Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation.
Bao L et al. Cancer Lett 2013; 337 (2):226-36 MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways.
Application : IHC-P
Reactivity : Mouse
Chen CH et al. Mol Ther 2013; 21 (3):670-9 Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction.
Application : ICC/IF
Reactivity : Mouse
Wang CH et al. Heart Vessels 2012; 27 (1):43382 Differentiation profile of peripheral blood-derived vascular progenitor cell predicts intimal hyperplasia after coronary stenting.
Grivennikov SI et al. Nature 2012; 491 (7423):254-8 Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Application : IHC
Reactivity : Mouse
Perone MJ et al. J Immunol 2009; 182 (5):2641-53 Suppression of autoimmune diabetes by soluble galectin-1.
Application : ICC/IF
Reactivity : Mouse
Clone Reference
Fatemeh Ajalloueian et al. Biomaterials 2014; 35 (22):5741-8 Constructs of electrospun PLGA, compressed collagen and minced urothelium for minimally manipulated autologous bladder tissue expansion
Application : IHC-P
Reactivity : Pig
Sandeep Goel et al. Reproduction 2008; 135 (6):785-95 Expression of NANOG, but not POU5F1, points to the stem cell potential of primitive germ cells in neonatal pig testis
Application : IHC-P
Reactivity : Pig
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