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Lalistat 2 [1234569-09-5]

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Référence NB-64-28291-10mg

Conditionnement : 10mg

Marque : Neo Biotech

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Lalistat 2

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Synonyms:

Catalog No. T41160 Copy Product Info

Purity: 99.84%

Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC₅₀ of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Cas No. 1234569-09-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.84%

Appearance:Solid

Color:White

Product Information

Lalistat 2 AI Summary

Lalistat 2 demonstrates significant bioactivity as an inhibitor of human Lysosomal Acid Lipase (LAL) and Mycobacterium tuberculosis H37Rv lipase. For human LAL, it reduces the enzyme decarbamoylation rate constant at a concentration of 10 µM after 30 minutes, with an activity rate of 0.001/min as measured by a fluorescence assay, and has an IC50 value of 152.0 nM under the same conditions. In the context of Mycobacterium tuberculosis H37Rv, Lalistat 2 shows a Minimum Inhibitory Concentration (MIC) of 25,000 nM, suggesting its efficacy in bacterial growth inhibition. The compound also demonstrates a ratio of MIC in the absence to presence of vancomycin of 4.0, indicating potential synergistic effects, and achieves a 55.0% growth inhibition in infected human monocyte-derived macrophages, underscoring its ability to inhibit bacterial proliferation within host cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC₅₀ of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

Chemical Properties

Molecular Weight	296.39
Formula	C₁₃H₂₀N₄O₂S
Cas No.	1234569-09-5
Smiles	O=C(Oc1nsnc1N1CCCCC1)N1CCCCC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (843.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.75 mM), Sonication is recommended.

10% DMSO+90% Saline: 10 mg/mL (33.74 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3739 mL	16.8697 mL	33.7393 mL	168.6966 mL
5 mM	0.6748 mL	3.3739 mL	6.7479 mL	33.7393 mL
10 mM	0.3374 mL	1.6870 mL	3.3739 mL	16.8697 mL
20 mM	0.1687 mL	0.8435 mL	1.6870 mL	8.4348 mL
50 mM	0.0675 mL	0.3374 mL	0.6748 mL	3.3739 mL
100 mM	0.0337 mL	0.1687 mL	0.3374 mL	1.6870 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

lysosomal acid lipase deficiencylysosomal acid lipaseLalistat-2Lalistat2Lalistat 2Inhibitorinhibitdried blood spotcholesteryl ester storage disease

Related Tags: Lalistat 2 chemical structure | Lalistat 2 formula | Lalistat 2 molecular weight