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> Mafosfamide [84211-05-2]

Mafosfamide [84211-05-2]

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Référence 015752-1mg

Conditionnement : 1mg

Marque : US Biological


015752 Mafosfamide

Mafosfamide
Structure of 015752|rel-2-[[(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]ethanesulfonic Acid Sodium; Mafosfamid Sodium; Z 7557; cis-Mafosfamide Sodium
Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

A Cyclophosphamide analog which induces apoptosis dose and time dependently in lymphoblastoid cells, with clearly more apoptosis in p53wt cells. Antitumor agent.

Synonyms:
rel-2-[[(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]ethanesulfonic Acid Sodium; Mafosfamid Sodium; Z 7557; cis-Mafosfamide Sodium

CAS No:
84211-05-2
Free Acid: 88859-04-5

Molecular Formula:
C9H18Cl2N2NaO5PS2

Molecular Weight:
423.25

Purity:
≥95%

Appearance:
White to pale beige solid

Melting Point:
>85°C (dec.) (lit)

Solubility:
DMSO (slightly), Methanol (slightly)

Method for Determining Identity:
Proton NMR and Mass Spectrometric Analysis

Elemental Analysis:
Calculated: %C: 24.54, %H: 4.29, %N: 6.62

Sodium:
As Reported

Atmosphere:
Inert gas

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Very Hygroscopic. Store under inert atmosphere.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999), 2. Lips, J., et al.: Carcinogenesis, 22, 579 (2001). 3. Ward, I., et al.: J. Biol. Chem., 276, 47759 (2001),. 4. Zhou, B., et al.: Cancer Biol. Ther., 2, S16 (2003). 5. Roos, W., et al.: Oncogene, 26, 186 (2007)