Monogalactosyl Diglyceride [41670-62-6]

Monogalactosyl Diglyceride belongs to the class of glycolipids and is composed of a diglyceride backbone attached to a single galactose sugar molecule. It is primarily studied in the fields of biochemistry, biophysics, and molecular biology. This compound has been investigated for its role in cellular processes, membrane structure, and signaling pathways. One of the key scientific applications of Monogalactosyl Diglyceride lies in its involvement in cell membrane organization and stability. It is a major constituent of cellular membranes, especially in plants and bacteria. By incorporating Monogalactosyl Diglyceride into artificial lipid bilayers or model membranes, researchers can study its impact on membrane properties, such as fluidity, permeability, and stability. Furthermore, Monogalactosyl Diglyceride has been recognized for its potential role in cell signaling and immune responses. It can modulate various cellular activities, including cell adhesion, migration, and receptor interactions. By studying its mechanisms of action, scientists aim to uncover its involvement in these processes and explore its potential as a therapeutic target for immune-related disorders. The precise mechanism of action of Monogalactosyl Diglyceride is complex and multifaceted. It interacts with other lipids, proteins, and carbohydrates in the cell membrane, influencing their spatial arrangement and functionality. This can impact membrane fluidity, protein localization, and signal transduction. Additionally, Monogalactosyl Diglyceride may serve as a ligand for specific receptors, triggering intracellular signaling cascades.

References:

1. Incorporation of fatty acids into monogalactosyl diglyceride and acylation of monogalactosyl monoglyceride by spinach leaf preparations.  |  Bajwa, SS. and Sastry, PS. 1975. Indian J Biochem Biophys. 12: 243-8. PMID: 1221025
2. Effect of carotenoids and monogalactosyl diglyceride on bacteriochlorophyll c aggregates in aqueous buffer: implications for the self-assembly of chlorosomes.  |  Klinger, P., et al. 2004. Photochem Photobiol. 80: 572-8. PMID: 15623345
3. Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate.  |  Amara, S., et al. 2009. Biochim Biophys Acta. 1791: 983-90. PMID: 19447192
4. Degradation of monogalactosyl diglyceride and digalactosyl diglyceride by sheep pancreatic enzymes.  |  Bajwa, SS. and Sastry, PS. 1974. Biochem J. 144: 177-87. PMID: 4462578
5. The involvement of lecithin and monogalactosyl diglyceride in linoleate synthesis by green and blue-green algae.  |  Appleby, RS., et al. 1971. Biochim Biophys Acta. 248: 205-11. PMID: 5002151
6. The association of the galactosyl diglycerides of brain with myelination. I. Changes in the concentration of monogalactosyl diglyceride in the somal and myelin fractions of brain of rats during development.  |  Inoue, T., et al. 1971. J Biol Chem. 246: 5688-94. PMID: 5096089
7. Positional distribution of fatty acids in monogalactosyl diglyceride fractions from leaves and algae. Structural and metabolic studies.  |  Safford, R. and Nichols, BW. 1970. Biochim Biophys Acta. 210: 57-64. PMID: 5456046
8. Changes in monogalactosyl diglyceride & other glyco & phospholipids in developing & aging chick cerebrum & cerebellum.  |  Singh, KN. and Subba Rao, K. 1979. Indian J Biochem Biophys. 16: 349-53. PMID: 548459
9. The metabolism of glyceride glycolipids. II. Biosynthesis of monogalactosyl diglyceride from uridine diphosphate galactose and diglyceride in brain.  |  Wenger, DA., et al. 1968. Biochemistry. 7: 3700-7. PMID: 5681471
10. Monogalactosyl diglyceride: a new neurolipid.  |  Steim, JM. 1967. Biochim Biophys Acta. 144: 118-26. PMID: 6055209
11. The transit sequence of a chloroplast precursor protein reorients the lipids in monogalactosyl diglyceride containing bilayers.  |  Chupin, V., et al. 1994. FEBS Lett. 350: 104-8. PMID: 8062905
12. Monogalactosyl diglyceride, a marker for myelination, activates oligodendroglial protein kinase C.  |  Schmidt-Schultz, T. and Althaus, HH. 1994. J Neurochem. 62: 1578-85. PMID: 8133286
13. Studies on the pathogenesis of Krabbe′s leukodystrophy: cellular reaction of the brain to exogenous galactosylsphingosine, monogalactosyl diglyceride, and lactosylceramide.  |  Suzuki, K., et al. 1976. Adv Exp Med Biol. 68: 99-114. PMID: 937124