Mouse Fadd activation kit by CRISPRa

CAT#: GA201350

Fadd CRISPRa kit - CRISPR gene activation of mouse Fas (TNFRSF6)-associated via death domain



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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Fadd
Locus ID 14082
Kit Components

GA201350G1, Fadd gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA201350G2, Fadd gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA201350G3, Fadd gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_010175
UniProt ID Q61160
Synonyms Mort1/FADD
Summary Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).[UniProtKB/Swiss-Prot Function]

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