Mouse IDE (Insulin Degrading Enzyme) Sandwich ELISA Kit E0009636)

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	IdeUniprot ID=IDE_MOUSE"
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Detected in brain and liver (at protein level). Detected in liver.
Post Translational Modifications
Function	Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin. Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia. Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP. Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients. Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.
Protein Name	Insulin-Degrading Enzyme Insulin Protease Insulinase Insulysin
Database Links
Cellular Localisation	Cytoplasm Cytosol Cell Membrane Secreted
Alternative ELISA Names	Insulin-Degrading Enzyme ELISA kit Insulin Protease ELISA kit Insulinase ELISA kit Insulysin ELISA kit Ide ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance