Mouse Notch1 activation kit by CRISPRa
CAT#: GA202936
Notch1 CRISPRa kit - CRISPR gene activation of mouse notch 1
Find the corresponding CRISPRi Inhibitor Kit
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Notch1 |
Locus ID | 18128 |
Kit Components | GA202936G1, Notch1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202936G2, Notch1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202936G3, Notch1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_008714 |
UniProt ID | Q01705 |
Synonyms | 9930111A19Rik; lin-12; Mis6; N1; Tan1 |
Summary | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).[UniProtKB/Swiss-Prot Function] |
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Other Versions
SKU | Description | Size | |
---|---|---|---|
KN311124 | Notch1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
KN311124BN | Notch1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
KN311124LP | Notch1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
KN311124RB | Notch1 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
KN511124 | Notch1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR |