Orb1220989-10mg | N-acetylcysteine amide [38520-57-9] Clinisciences

N-acetylcysteine amide

SKU: orb1220989

Description

N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent.(In Vitro):N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR). N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death.(In Vivo):N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, i.p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	38520-57-9
MW	282.34
Purity	>98% (HPLC)
Formula	C₈H₁₄N₂O₅S₂
SMILES	CC(=O)N[C@@H](CS)C(N)=O
Target	ROS
Solubility	DMSO:100 mg/mL (616.48 mM)

Bioactivity

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In Vivo	N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, i.p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats.
In Vitro	N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR). N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death.

In Vivo

N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, i.p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats.

In Vitro

N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR). N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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N-acetylcysteine amide [orb1301727]
Purity:
≥98% (May vary between batches)
CAS Number:
38520-57-9
MW:
162.21
Formula:
C₅H₁₀N₂O₂S
Sizes Available: 10 mg, 50 mg, 100 mg, 5 mg, 25 mg, 2 mg, 500 mg, 1 ml x 10 mM (in DMSO)
N-Acetylcysteine amide [orb1966049]
CAS Number:
38520-57-9
MW:
162.21
Formula:
C₅H₁₀N₂O₂S

Quick Database Links

Gene Symbol

ROS

N-acetylcysteine amide [38520-57-9]

Référence orb1220989-10mg

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