N-Cadherin (a.a. 853-864) Peptide
Référence MBS474013-0,05mg
Conditionnement : 0.05mg
Marque : MyBiosource
N-Cadherin (A.a. 853-864) Peptide – Synthetic Peptide
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS474013Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the cadherin-mediated adhesion may be by… More details
Product Overview
Online Datasheet in PDFProduct Name
N-Cadherin (a.a. 853-864) Peptide (CDH2), Peptide
Full Product Name
N-Cadherin (a.a. 853-864) Peptide
Product Gene Name
CDH2 peptide
Sequence
Peptide Sequence: Unphosphor ylated N-Cadherin synthetic peptide correspond ing to amino acids 853 to 864 in human N-cadherin . This sequence is conserved in rat and mouse N-cadherin , as well as in E-, P-, and R-cadherin from human, rat, and mouse.
Form/Format
Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.
Specificity
The peptide is specifically recognized by anti-N-Cadherin (a.a. 853-864) antibody (CP1901) in ELISA, and has been shown to block the reactivity of CP1901 during Western blot. In addition, the peptide is recommended for use in blocking CP1901 reactivity in immunocytochemistry.
Preparation and Storage
Store at -20 degree C. Stable for 1 year.
Molecular Weight
99,809 Da
Chromosome Location
Chromosome: 18; NC_000018.9 (25530930..25757445, complement). Location: 18q11.2
OMIM
114020
Application Notes for CDH2 peptide
ELISA: 50 ng/well
Western Blot: 1 mg/ml
Western Blot: 1 mg/ml
Product References and Citations for CDH2 peptide
• Xu, Y. et al. (1997) J. Biol. Chem. 272(21):13463
• Xu, Y. & Carpenter, G. (1999) J. Cell. Bioch. 75:264.
• Qi, J. et al. (2006) Mol. Biol. Cell 17(3):1261.
• Xu, Y. & Carpenter, G. (1999) J. Cell. Bioch. 75:264.
• Qi, J. et al. (2006) Mol. Biol. Cell 17(3):1261.
Other Notes
Small volumes of CDH2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CDH2 purchase
MBS474013 is a peptide targeting CDH2. Also known as N-Cadherin (a.a. 853-864) Peptide.
Additional Details
NCBI/Uniprot data below describe general gene information for CDH2. It may not necessarily be applicable to this product.
NCBI Official Full Name
N-cadherin
NCBI Official Synonym Full Names
cadherin 2, type 1, N-cadherin (neuronal)
NCBI Official Symbol
CDH2
NCBI Official Synonym Symbols
CDHN; NCAD; CD325; CDw325
UniProt Protein Name
Cadherin-2
UniProt Synonym Protein Names
CDw325; Neural cadherin
Protein Family
Cadherin
UniProt Gene Name
CDH2
UniProt Synonym Gene Names
CDHN; NCAD
UniProt Entry Name
CADH2_HUMAN
NCBI Protein Information
cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; OTTHUMP00000066304; OTTHUMP00000067378; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal
NCBI Summary for CDH2
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq]
Show more UniProt Comments for CDH2
Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density
Subunit structure: Interacts with CDCP1. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway
By similarity. Ref.10
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Sequence similarities: Contains 5 cadherin domains.
Show more Subunit structure: Interacts with CDCP1. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway
By similarity. Ref.10
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Sequence similarities: Contains 5 cadherin domains.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with CDH2 peptide
| Reference Product | PubMed Publications |
|---|---|
| CTNNB1 peptide | >44 publications with CDH2 and CTNNB1 |
| CDH4 peptide | >3 publications with CDH2 and CDH4 |
| JUP peptide | >2 publications with CDH2 and JUP |
| CDH11 peptide | >2 publications with CDH2 and CDH11 |
| CTNNA1 peptide | >1 publications with CDH2 and CTNNA1 |
| ARVCF peptide | >1 publications with CDH2 and ARVCF |
Pathways associated with CDH2 peptide
| Products by Pathway | Pathway Diagram |
|---|---|
| Adherens Junctions Interactions Pathway antibodies | Adherens Junctions Interactions Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram |
| CDO In Myogenesis Pathway antibodies | CDO In Myogenesis Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cell Junction Organization Pathway antibodies | Cell Junction Organization Pathway Diagram |
| Cell-cell Junction Organization Pathway antibodies | Cell-cell Junction Organization Pathway Diagram |
| FGF Signaling Pathway antibodies | FGF Signaling Pathway Diagram |
| Myogenesis Pathway antibodies | Myogenesis Pathway Diagram |
Diseases associated with CDH2 peptide
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >63 publications with CDH2 and Neoplasms |
| Carcinoma Antibodies | >25 publications with CDH2 and Carcinoma |
| Adenocarcinoma Antibodies | >18 publications with CDH2 and Adenocarcinoma |
| Female Urogenital Diseases Antibodies | >11 publications with CDH2 and Female Urogenital Diseases |
| Neuroectodermal Tumors Antibodies | >11 publications with CDH2 and Neuroectodermal Tumors |
| Cardiovascular Diseases Antibodies | >11 publications with CDH2 and Cardiovascular Diseases |
| Neoplasm Metastasis Antibodies | >11 publications with CDH2 and Neoplasm Metastasis |
| Skin Diseases Antibodies | >9 publications with CDH2 and Skin Diseases |
| Endocrine Gland Neoplasms Antibodies | >9 publications with CDH2 and Endocrine Gland Neoplasms |
| Lung Neoplasms Antibodies | >9 publications with CDH2 and Lung Neoplasms |
Organs/Tissues associated with CDH2 peptide
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >27 publications with CDH2 and Brain |