N-Glycolylneuraminic acid
Référence M19972-10mg
Conditionnement : 10mg
Marque : AbMole Bioscience
NeuGc; GcNeu
Quality Control & Documentation
Biological Activity
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs).
Chemical Information
Molecular Weight | 325.27 |
Formula | C11H19NO10 |
CAS Number | 1113-83-3 |
Solubility (25°C) | Water ≥ 60 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Cindy M Spruit, et al. J Virol. N-Glycolylneuraminic Acid Binding of Avian and Equine H7 Influenza A Viruses
[2] Renato Mastrangeli, et al. Trends Pharmacol Sci. Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins
[3] Sharon Yehuda, et al. Front Immunol. Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid
[4] Andrea Perota, et al. Front Immunol. N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)
[5] Anoopjit Singh Kooner, et al. Front Immunol. Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides