Conditionnement : 100ug
Synonyms: N-methyl Leukotriene C4
| Description | N-methyl Leukotriene C4 (250 μg/ml solution in ethanol) is a metabolically stable synthetic analogue of Leukotriene C4 that resists enzymatic conversion into LTD4 and LTE4. N-methyl Leukotriene C4 is a valuable experimental tool for investigations involving leukotriene signaling, inflammatory mediator biology, eicosanoid metabolism, and receptor-associated inflammatory pathways. |
| In vitro | N-methyl Leukotriene C4 (NMLTC4) behaves as a full agonist at human CysLT2 receptor with EC50 value >2000 nM by β-galactosidase-β-arrestin assay[1]. |
| In vivo | N-methyl Leukotriene C4 (NMLTC4) (10μL; intradermal injection) elicited a large, statistically significant increase in Evans Blue dye leakage in the TG-EC mice. [1] |
| Synonyms | N-methyl Leukotriene C4 |
| Molecular Weight | 639.80 |
| Formula | C31H49N3O9S |
| Cas No. | 131391-65-6 |
| Smiles | [C@@H](CS[C@@H]([C@H](CCCC(O)=O)O)/C=C/C=C/C=C\C/C=C\CCCCC)(NC(CC[C@@H](C(O)=O)NC)=O)C(NCC(O)=O)=O |
| Relative Density. | 1.202 g/cm3 (Predicted) |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMF: 25 mg/mL (39.07 mM), Sonication is recommended. DMSO: 25 mg/mL (39.07 mM), Sonication is recommended. PBS (pH 7.2): < 1 mg/mL (insoluble), Sonication is recommended. Ethanol:H2O (95:5): 1 mg/mL (1.56 mM), Sonication is recommended. Ethanol: < 1 mg/mL (insoluble), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
Ethanol:H2O (95:5)/DMF/DMSO
DMF/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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