Nootkatone [4674-50-4]
Référence T3S0195-500mg
Conditionnement : 500mg
Marque : TargetMol
Nootkatone
Nootkatone
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Cas No. 4674-50-4
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.4%
Color:White
COA HNMR HPLC
Product Introduction
Nootkatone AI Summary
Nootkatone exhibits a range of bioactivities across different biological systems. It effectively inhibits cell degranulation in rat RBL2H3 cells and demonstrates significant inhibition of LPS-induced nitric oxide (NO) production in ddY mouse macrophages, with an IC50 value of 34000.0 nM. Additionally, it has antiproliferative effects against human A549 and HL60 cells, with ID50 values of 58.4 µg/ml and 4.27 µg/ml, respectively. The compound also shows activity against human liver transporters, significantly inhibiting OATP2B1 and slightly inhibiting OATP1B3, while stimulating OATP1B1. In terms of insect repellency, it is effective against Coptotermes formosanus at a concentration of 12.5 µg/g up to 24 hours, and it exhibits cytotoxicity against mouse BV2 cells with a maximum non-toxic concentration of 0.1 µM. Furthermore, Nootkatone acts as an antagonist at human TRPV1 and ORAI1 receptors at 90 µM, impacting capsaicin-induced inward currents. It also inhibits CYP2C19 enzyme activity, showing 70.0% inhibition at 1 µM and 21.9% inhibition at 10 µM concentrations relative to control..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver. |
| Molecular Weight | 218.33 |
| Formula | C15H22O |
| Cas No. | 4674-50-4 |
| Smiles | C[C@@H]1CC(=O)C=C2CC[C@H](C[C@@]12C)C(C)=C |
| Relative Density. | 0.997 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (1145.06 mM), Sonication is recommended.  Ethanol: Slightly soluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.16 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||