Paclobutrazol

Biological Activity

Paclobutrazol is a new, high-efficiency, low-toxicity plant growth regulator that can inhibit the production of gibberellin derivatives and reduce the division and elongation of plant cells. Paclobutrazol is easily absorbed by roots, stems, and leaves, and is conducted through the xylem of the plant. Paclobutrazol also has a bactericidal effect. Paclobutrazol has a wide range of activities on gramineous plants, which can make the plant stem internodes stout, reduce lodging and increase yield.

Chemical Information

Molecular Weight	293.79
Formula	C15H20ClN3O
CAS Number	76738-62-0
Form	Solid
Solubility (25°C)	Methanol ≥ 50 mg/mL
Storage	2-8°C, dry, protect from light, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yun Luo, et al. Paclobutrazol exposure induces apoptosis and impairs autophagy in hepatocytes via the AMPK/mTOR signaling pathway

[2] Hongwei Zhao, et al. Chiral enantiomers of the plant growth regulator paclobutrazol selectively affect community structure and diversity of soil microorganisms

[3] Hao-Ming Guo, et al. The potential risks of paclobutrazol residue on yogurt fermentation from the level of chiral enantiomers

[4] Hao-Ming Guo, et al. Enantiomeric effect of paclobutrazol on the microorganism composition during wine fermentation

[5] Xiulan Jiang, et al. Environmental behavior of paclobutrazol in soil and its toxicity on potato and taro plants