PathPlus™ ADAMTS5 Antibody (Metalloprotease Domain)
Référence LS-A7761-50
Conditionnement : 50ul
Marque : LSBio
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Téléphone : +1 850 650 7790
Overview
Antibody:
ADAMTS5 Rabbit anti-Human Polyclonal (Metalloprotease Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Dog, Hamster, Horse
Format:
Unconjugated, Unmodified
Specifications
Description
ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human ADAMTS5
Synonyms
ADAMTS5 | Aggrecanase-2 | ADAM-TS 11 | ADAM-TS5 | ADAMTS-11 | ADAMTS11 | ADAM-TS 5 | ADAMTS-5 | ADMP-2 | ADMP2
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Dog, Hamster, Horse (tested or 100% immunogen sequence identity)
Predicted
Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from Metalloprotease domain of human ADAMTS5. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Horse (100%); Pig (94%); Bovine, Opossum, Xenopus (89%); Lizard (83%).
Epitope
Metalloprotease Domain
Specificity
Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (3 µg/ml)
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee About ADAMTS5
Q9UNA0 NM_007038 NP_008969.2
Validation
Colon, Carcinoma
Breast, carcinoma
Lung, non small cell carcinoma
Anti-ADAMTS5 antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Breast, Carcinoma
Lung, Non Small-Cell Carcinoma
Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
tech@clinisciences.com