Phenytoin
Référence M5875-100mg
Conditionnement : 100mg
Marque : AbMole Bioscience
Synonym:
Diphenylhydantoin; 5,5-Diphenylhydantoin
Quality Control & Documentation
Biological Activity
Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin reduces breast tumour growth and metastasis in mice, and it also has antiepileptic activity.
Chemical Information
Molecular Weight | 252.27 |
Formula | C15H12N2O2 |
CAS Number | 57-41-0 |
Solubility (25°C) | DMSO 50 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Franco V, et al. Expert Opin Drug Metab Toxicol. CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.