Phosphatidylserine

Biological Activity

Chemical Information

Molecular Weight	792.07
Formula	C42H82NO10P
CAS Number	51446-62-9
Solubility (25°C)	Soluble in chloroform
Storage	-20°C, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bhupender Sharma, et al. Semin Cancer Biol. Phosphatidylserine: A cancer cell targeting biomarker

[2] Maryam Darabi, et al. Curr Opin Lipidol. Phosphatidylserine in atherosclerosis

[3] Katsumori Segawa, et al. Trends Cell Biol. An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure

[4] Michael J Glade, et al. Nutrition. Phosphatidylserine and the human brain

[5] Peter A Leventis, et al. Annu Rev Biophys. The distribution and function of phosphatidylserine in cellular membranes