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> Polydextrose [68424-04-4]

Polydextrose [68424-04-4]

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Référence HY-W134326-250g

Conditionnement : 250g

Marque : MedChemExpress


Description

Polydextrose is an orally active prebiotic. Polydextrose promotes the growth of Pediococcus pentosaceus ATCC 43200. Polydextrose reduces cholesterol and synergistically lowers blood sugar with Sitagliptin (HY-13749). Currently, it is mainly used in the research of diseases such as hyperlipidemia, type 2 diabetes, and postoperative iron deficiency anemia[1][2][3][4][5].

In Vitro

Polydextrose (0.5%-1.5%; 24 h; pH 6.0, 35°C, 50-150 rpm) significantly promotes the growth of Pediococcus pentosaceus ATCC 43200 in MRS medium and increases the lactic acid yield[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polydextrose Related Antibodies
In Vivo

Polydextrose (6%; p.o. via diets; 3-4 weeks) significantly reduces plasma and liver cholesterol levels in cholesterol-fed gerbils with an expanded endogenous cholesterol pool, without significantly affecting body and organ weights[1].
Polydextrose (7.5%; p.o. via diets; 60-day administration period) increases cecal SCFAs concentration (acetate by 198.4%), decreases cecal pH, and increases hemoglobin (29.2%) and hematocrit (55.8%) in rats undergoing partial gastrectomy (Billroth II procedure + vagotomy)[4]
Polydextrose (0.25 g/day; p.o.; daily; 6 weeks) combined with Sitagliptin (HY-13749) significantly reduces the area under the curve of the oral glucose tolerance test (by 28%) and glycaemia in high-fat diet-induced diabetic mice, and increases portal vein GLP-1 concentration[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
Formule

C12H22O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]1CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O.4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (Need ultrasonic)

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  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
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