Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> Polymyxin B [1404-26-8]

Polymyxin B [1404-26-8]

Imprimer Imprimer
Identifiez-vous

Référence orb1944475-50mg

Conditionnement : 50mg

Marque : Biorbyt

Polymyxin B [[1404-26-8]]

Polymyxin B

SKU: orb1944475

Description

Polymyxin B is a polymyxin-class antibiotic that disrupts Gram-negative bacterial membranes by binding to lipopolysaccharide (LPS). It is a critical research tool for studying extensively drug-resistant (XDR) Gram-negative infections and endotoxemia in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Images & Validation

−
Polymyxin B

Key Properties

−
CAS Number1404-26-8
Purity91.00% (May vary between batches)
TargetAntibacterial,Antibiotic
SolubilityH2O:16.67 mg/mL

Bioactivity

−
In Vivo
Polymyxin B was administered intravenously once daily for seven consecutive days at a dose range of 5-20 mg/kg Polymyxin B. The treatment of PBMCs with Polymyxin B for six hours reduced TNF-α and IL-10 production. A nephrotoxicity endpoint was observed in the Sprague-Dawley rat model at the 20 mg/kg dose, whereas no such endpoint was observed at the 5 mg/kg dose.
In Vitro
10 μg/mL Polymyxin B, treated for 6 hours, reduced TNF-α and IL-10 production in human peripheral blood mononuclear cells (PBMCs).

Storage & Handling

−
Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
Antibiotic, Bacterial
−
  • Polymyxin B, mAb 45 Antibody

    Polymyxin B, mAb 45 Antibody [orb1109015]

    IA,  WB

    Bacteria

    Monoclonal

    Unconjugated

    200 μg
  • Endotoxin Removal Kit (Polymyxin B)

    Endotoxin Removal Kit (Polymyxin B) [orb1173385]

    1 ml, 5 x 1 ml
  • Endotoxin Removal Resin

    Endotoxin Removal Resin [orb1173386]

    25 ml, 5 ml
  • Polymyxin B

    Polymyxin B [orb3011939]

    0.15-10ng/mL

    0.07ng/mL

    48 T, 96 T, 5 x 96 T
  • PBS2 Antibody

    PBS2 Antibody [orb847008]

    ELISA,  WB

    Bacteria

    Rabbit

    Polyclonal

    Unconjugated

    2 mg

Quick Database Links

Gene Symbol
Antibacterial,Antibiotic

Protocol Information