PTPN6(Tyr536) Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
Référence bs-5577R-A488
Conditionnement : 100ul
Marque : Bioss
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PTPN6(Tyr536) Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-5577R-A488 |
| Product Name | PTPN6(Tyr536) Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated |
| Applications | WB, FCM, IF(IHC-P), IF(ICC) |
| Reactivity | Human, Mouse |
| Predicted Reactivity | Dog, Horse |
| Specifications | |
| Conjugation | ALEXA FLUOR® 488 |
| Host | Rabbit |
| Source | KLH conjugated synthetic phosphopeptide derived from human PTPN6 around the phosphorylation site of Tyr536 [SE(p-Y)GN] |
| Modification Site | Tyr536 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 5777 |
| Swiss Prot | P29350 |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | SHP-1Tyr536; PTPN6phospho Y536; SHP1phospho Y536; 70 kda SHP1L protein; HCP; HCPH; Hematopoietic cell phosphatase; Hematopoietic cell protein tyrosine phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; Protein tyrosine phosphatase 1C; Protein tyrosine phosphatase non receptor type 6; Protein tyrosine phosphatase SHP1; PTP1C; PTPN6; SH PTP 1; SHP1; SHP1L; PTN6_HUMAN. |
| Background | SHP1 is a member of the non receptor protein tyrosine phosphatase subfamily. The PTP family comprises of at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is cytosolic. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. SHP1 is implicated in the control of tyrosine kinase signalling pathways in cellular proliferation, with a potential role in cancer. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |
| IF(IHC-P) | 1:50-200 |
| IF(ICC) | 1:50-200 |